Randomized trial of the effect of drug presentation on asthma outcomes: The American Lung Association Asthma Clinical Research Centers Robert A. Wise,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Adherence with montelukast or fluticasone in a long-term clinical trial: Results from the Mild Asthma Montelukast Versus Inhaled Corticosteroid Trial

Susan L. Limb, MD, Kathryn C. Brown, MD, Robert A. Wood, MD, Robert A

Risk of an asthma exacerbation after bariatric surgery in adults

A cluster-randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma L. Keoki Williams, MD, MPH,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Fluticasone furoate nasal spray: A single treatment option for the symptoms of seasonal allergic rhinitis Harold B. Kaiser, MD, Robert M. Naclerio, MD,

Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults Peter S. Creticos, MD, Jennifer Maloney,

Effect of montelukast for treatment of asthma in cigarette smokers

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial Pierluigi Paggiaro,

Is 9 more than 2 also in allergic airway inflammation?

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Mothers' anxiety during pregnancy is associated with asthma in their children Hannah Cookson, MB, ChB, Raquel Granell, PhD, Carol Joinson, PhD, Yoav Ben-Shlomo,

Advancing asthma care: The glass is only half full!

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16- Arg/Arg patients with asthma Eric D. Bateman, MD, Oliver Kornmann,

The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: A systematic review and meta-analysis of randomized controlled trials

Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis George Philip, MD, Janet van Adelsberg, MD, Thomas Loeys, PhD, Nancy.

Validation of the Pregnancy Asthma Control Test

Physician needs in health informatics: Just ask the docs

Treatment of chronic autoimmune urticaria with omalizumab

A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine–refractory chronic idiopathic urticaria

Nonadherence to Asthma Treatment: Getting Unstuck

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Aimee L. Speck, MD, Michael Hess, MSI, Alan P. Baptist, MD, MPH

Effects of formoterol or salmeterol on impulse oscillometry in patients with persistent asthma Arvind Manoharan, MBChB, Alexander von Wilamowitz-Moellendorff,

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects William Busse, MD, Sheldon Spector, MD, Karin Rosén,

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Sharon Seth, MD, David A. Khan, MD

What is an “eosinophilic phenotype” of asthma?

Medication use in children with asthma in Finland from 1995 to 2006

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Adherence with montelukast or fluticasone in a long-term clinical trial: Results from the Mild Asthma Montelukast Versus Inhaled Corticosteroid Trial

Advances in the approach to the patient with food allergy

Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab Donald W. MacGlashan,

Corinne A. Keet, MD, MS, Wayne G. Shreffler, MD, PhD, Roger D

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Risk of oral food challenges

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma Anne E. Dixon, MA, BM BCh,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Pınar Uysal, MD, Esben Eller, MSc, PhD, Charlotte G

Measles and immunomodulation

Guus A. Westerhof, MD, Elise M. Vollema, MD, Els J

Problem solving to improve adherence and asthma outcomes in urban adults with moderate or severe asthma: A randomized controlled trial Andrea J. Apter,

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16- Arg/Arg patients with asthma Eric D. Bateman, MD, Oliver Kornmann,

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization.

Environmental factors and eosinophilic esophagitis

Advances in pediatric asthma in 2007

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Negative affect, medication adherence, and asthma control in children

Safety and efficacy of repeated monthly carboplatin desensitization

Natural history of cow’s milk allergy

Presentation transcript:

Randomized trial of the effect of drug presentation on asthma outcomes: The American Lung Association Asthma Clinical Research Centers Robert A. Wise, MD, Susan J. Bartlett, PhD, Ellen D. Brown, MS, Mario Castro, MD, Rubin Cohen, MD, Janet T. Holbrook, PhD, Charles G. Irvin, PhD, Cynthia S. Rand, PhD, Marianna M. Sockrider, MD, Elizabeth A. Sugar, PhD Journal of Allergy and Clinical Immunology Volume 124, Issue 3, Pages 436-444.e8 (September 2009) DOI: 10.1016/j.jaci.2009.05.041 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Enrollment, randomization, and follow-up of study participants. All patients for whom follow-up data were available were included in the analysis, regardless of whether they discontinued treatment. Participants assigned to the ”Regular“ presentation received a neutral message about drug efficacy. Those assigned to Usual Care received no drug treatment and were only given asthma education brochures. Journal of Allergy and Clinical Immunology 2009 124, 436-444.e8DOI: (10.1016/j.jaci.2009.05.041) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Factorial treatment combinations that were randomly assigned in order to determine the main and interactive effects of drug assignment and treatment presentation. A fifth group received usual care. Journal of Allergy and Clinical Immunology 2009 124, 436-444.e8DOI: (10.1016/j.jaci.2009.05.041) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

This figure illustrates the study schema This figure illustrates the study schema. Asthma diaries and daily peak expiratory flows (PEF) were collected for two weeks prior to randomization and during four weeks of treatment. Asthma symptoms and lung function were assessed at baseline and after two weeks and four weeks of treatment. Journal of Allergy and Clinical Immunology 2009 124, 436-444.e8DOI: (10.1016/j.jaci.2009.05.041) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

This figure illustrates one of the panels in the computer presentation including messages such as branding (Singulair), Authority (FDA, Merck) and Peer identification (attractive healthy adult of indeterminate age and race). Journal of Allergy and Clinical Immunology 2009 124, 436-444.e8DOI: (10.1016/j.jaci.2009.05.041) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions