Robert A. Wild, M. D. , Manfredi Rizzo, M. D. , Sheri Clifton, Ph. D

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Presentation transcript:

Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis Robert A. Wild, M.D., Manfredi Rizzo, M.D., Sheri Clifton, Ph.D., Enrico Carmina, M.D. Fertility and Sterility Volume 95, Issue 3, Pages 1073-1079.e11 (March 2011) DOI: 10.1016/j.fertnstert.2010.12.027 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Forest plot of comparison: triglycerides in polycystic ovary syndrome (PCOS) versus control subjects (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data, “b” refers to nonobese, and “c” refers to ovulatory PCOS compared with control subjects. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Forest plot of comparison: high-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control subjects (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data, “b” refers to nonobese, and “c” refers to ovulatory PCOS compared with control subjects. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Forest plot of comparison: low-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control subjects (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data, “b” refers to nonobese, and “c” refers to ovulatory PCOS compared with control subjects. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Forest plot of comparison: nonhigh-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control subjects (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data, “b” refers to nonobese, and “c” refers to ovulatory PCOS compared with control subjects. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Flowchart showing the number of papers retrieved by individual searches, and number of included and excluded papers. NIH = National Institutes of Health; PCOS = polycystic ovary syndrome. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Forest plot of comparison: low-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control women (mg/dL) with body mass index ≤25. Studies are ordered by year of publication; “a” means weight-matched data. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Forest plot of comparison: low-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control women (mg/dL) with body mass index >25. Studies are ordered by year of publication; “a” means weight-matched data. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Forest plot of comparison: National Institutes of Health criteria only—triglycerides in polycystic ovary syndrome (PCOS) versus control women (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Forest plot of comparison: Rotterdam criteria only—triglycerides in polycystic ovary syndrome (PCOS) versus control women (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Forest plot of comparison: NIH criteria only—nonhigh-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control women (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Forest plot of comparison: Rotterdam criteria only—nonhigh-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control women (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Forest plot of comparison: NIH criteria only—low-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control women (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data, “b” refers to nonobese, and “c” refers to ovulatory PCOS compared with control subjects. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Forest plot of comparison: Rotterdam criteria only—low-density lipoprotein cholesterol in polycystic ovary syndrome (PCOS) versus control women (mg/dL). Studies are ordered by year of publication; “a” means weight-matched data, “b” refers to nonobese, and “c” refers to ovulatory PCOS compared with control subjects. Fertility and Sterility 2011 95, 1073-1079.e11DOI: (10.1016/j.fertnstert.2010.12.027) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions