Thymic Selection: To Thine Own Self Be True

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Thymic Selection: To Thine Own Self Be True Alexandra Kitz, David A. Hafler Immunity Volume 42, Issue 5, Pages 788-789 (May 2015) DOI: 10.1016/j.immuni.2015.05.007 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Clonal Deletion Prunes the T Cell Repertoire without Eliminating Self-Reactive T Cells Self-reactive CD8 T cells can escape clonal deletion. Upon activation in the periphery, however, self-reactive T cells show a lower activation profile and a differential gene-expression pattern compared to foreign-reactive CD8 T cells. Immunity 2015 42, 788-789DOI: (10.1016/j.immuni.2015.05.007) Copyright © 2015 Elsevier Inc. Terms and Conditions