Pausing to Regroup: Thalamic Gating of Cortico-Basal Ganglia Networks

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Pausing to Regroup: Thalamic Gating of Cortico-Basal Ganglia Networks Catherine A. Thorn, Ann M. Graybiel Neuron Volume 67, Issue 2, Pages 175-178 (July 2010) DOI: 10.1016/j.neuron.2010.07.010 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 A salient stimulus, such as the honking horn of an oncoming truck, is thought to elicit a burst of thalamic activity. In this issue of Neuron, Ding et al. show that such thalamic stimulation excites a burst-and-pause response in the cholinergic interneurons of the striatum. The resulting burst of acetylcholine (ACh) causes a brief decrease in cortico-striatal synaptic transmission to medium spiny neurons (MSNs) in both the direct and indirect pathways, via activation of presynaptic M2/M4 receptors. This is then followed by prolonged facilitation of transmission in the indirect, but not the direct, pathway, caused by activation of postsynaptic M1 receptors on MSNs in the indirect pathway. Neuron 2010 67, 175-178DOI: (10.1016/j.neuron.2010.07.010) Copyright © 2010 Elsevier Inc. Terms and Conditions