Adriana K. Burlá, Núbia S. Lobato, Zuleica B

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Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats Adriana K. Burlá, Núbia S. Lobato, Zuleica B. Fortes, Wille Oigman, Mario Fritsch Neves International Journal of Cardiology Volume 165, Issue 3, Pages 483-487 (May 2013) DOI: 10.1016/j.ijcard.2011.09.012 Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Systolic blood pressure (BP) (A), plasma glucose (B), plasma insulin (C) and Homeostasis Model Assessment (HOMA-IR) (D) in all groups. Results are presented as mean±SEM. International Journal of Cardiology 2013 165, 483-487DOI: (10.1016/j.ijcard.2011.09.012) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Representative images of optical microscopy showing interstitial (upper images) and perivascular (lower images) collagen density in all groups. Increased media-to-lumen ratio of intramyocardial arterioles may also be observed in MSG groups. International Journal of Cardiology 2013 165, 483-487DOI: (10.1016/j.ijcard.2011.09.012) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions