M.A.M. Rogers, D.M. Aronoff Clinical Microbiology and Infection

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The influence of non-steroidal anti-inflammatory drugs on the gut microbiome M.A.M. Rogers, D.M. Aronoff Clinical Microbiology and Infection Volume 22, Issue 2, Pages 178.e1-178.e9 (February 2016) DOI: 10.1016/j.cmi.2015.10.003 Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Gut bacterial operational taxonomic units (OTUs) for participants using only one medication vs. participants using no medication. Clinical Microbiology and Infection 2016 22, 178.e1-178.e9DOI: (10.1016/j.cmi.2015.10.003) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Prevalence of gut bacterial families for participants using only non-steroidal anti-inflammatory drugs (NSAIDs) vs. participants not using medication. Clinical Microbiology and Infection 2016 22, 178.e1-178.e9DOI: (10.1016/j.cmi.2015.10.003) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Receiver operating characteristic curves for participants using (a) non-steroidal anti-inflammatory drugs or (b) naproxen, showing discrimination by age, gender, and microbiome data. AUC, area under the curve. Clinical Microbiology and Infection 2016 22, 178.e1-178.e9DOI: (10.1016/j.cmi.2015.10.003) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 4 Heat-map for bacterial families, showing differences in relative abundance by medication use. Clinical Microbiology and Infection 2016 22, 178.e1-178.e9DOI: (10.1016/j.cmi.2015.10.003) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 5 Principal component analysis biplot of bacteria to distinguish ibuprofen users from naproxen users. Clinical Microbiology and Infection 2016 22, 178.e1-178.e9DOI: (10.1016/j.cmi.2015.10.003) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 6 Relative abundance of bacterial operational taxonomic units (OTUs) by medication type. Abx, antibiotic; ATD, antidepressant; H2R, H2 receptor antagonist; Lax, laxative; NSAID, non-steroidal anti-inflammatory drug; PPI, proton-pump inhibitor. Clinical Microbiology and Infection 2016 22, 178.e1-178.e9DOI: (10.1016/j.cmi.2015.10.003) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions