Omalizumab facilitates rapid oral desensitization for peanut allergy

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Presentation transcript:

Omalizumab facilitates rapid oral desensitization for peanut allergy Andrew J. MacGinnitie, MD, PhD, Rima Rachid, MD, Hana Gragg, MPH, Sara V. Little, BA, Paul Lakin, MS, Antonella Cianferoni, MD, Jennifer Heimall, MD, Melanie Makhija, MD, Rachel Robison, MD, R. Sharon Chinthrajah, MD, John Lee, MD, Jennifer Lebovidge, PhD, Tina Dominguez, PA, Courtney Rooney, RN, Megan Ott Lewis, MSN, CRNP, Jennifer Koss, RN, Elizabeth Burke-Roberts, MSN, CPNP, Kimberly Chin, BA, Tanya Logvinenko, PhD, Jacqueline A. Pongracic, MD, Dale T. Umetsu, MD, PhD, Jonathan Spergel, MD, PhD, Kari C. Nadeau, MD, PhD, Lynda C. Schneider, MD Journal of Allergy and Clinical Immunology Volume 139, Issue 3, Pages 873-881.e8 (March 2017) DOI: 10.1016/j.jaci.2016.08.010 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study enrollment, randomization, procedures, and outcomes. OL, Open label. OL also indicates subjects who were considered to have failed peanut OIT and went on to receive open-label omalizumab. Journal of Allergy and Clinical Immunology 2017 139, 873-881.e8DOI: (10.1016/j.jaci.2016.08.010) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Highest dose of peanut protein tolerated during initial rapid desensitization. Journal of Allergy and Clinical Immunology 2017 139, 873-881.e8DOI: (10.1016/j.jaci.2016.08.010) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Changes in immunologic characteristics. Wheal size for peanut SPTs (A) and peanut-specific IgE measurements (B) are shown at baseline and week 31 of the study after 12 weeks off study drug. OL, Open-label. Journal of Allergy and Clinical Immunology 2017 139, 873-881.e8DOI: (10.1016/j.jaci.2016.08.010) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions