Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis

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Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis T. Wang, C.-Y. Wen, C.-H. Yan, W.-W. Lu, K.-Y. Chiu Osteoarthritis and Cartilage Volume 21, Issue 4, Pages 574-581 (April 2013) DOI: 10.1016/j.joca.2013.01.002 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 (a) Demographic Micro-CT image showed narrowed joint space of DH strain guinea pigs at age of 1 and 2 months; (b) Overall view of knee joint histology with Toluidine blue staining of DH and BS2 strain guinea pigs. Obvious cartilage destruction was observed in neither strain; (c) Modified Mankin score showed no significant difference in joint degeneration between BS2 and DH strain guinea pigs at 1, 2 and 3 months; (d) Quantitative analysis showed the joint space in DH strain guinea pig was significantly narrower than BS2 at 1 and 2 months. Osteoarthritis and Cartilage 2013 21, 574-581DOI: (10.1016/j.joca.2013.01.002) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Micro-CT analysis of tibia subchondral plate. (a) Demographic images of top and coronal views of ROI selection of medial and lateral tibia subchondral plate for analysis of subchondral plate BMD, thickness and porosity; (b) Quantitative analysis of BMD showed significant difference between DH and BS2 strain on medial sides at age of 2 and 3 months; (c) Quantitative analysis of subchondral plate thickness showed significant difference between DH and BS2 strain on medial sides at age of 1, 2 and 3 months; (d) Quantitative analysis of subchondral plate porosity showed significant difference between DH and BS2 strain on medial sides at age of 1, 2 and 3 months, while within DH group, significant difference was defined between medial and lateral sides at age of 2 and 3 months. Osteoarthritis and Cartilage 2013 21, 574-581DOI: (10.1016/j.joca.2013.01.002) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Micro-CT analysis of tibia subchondral trabecular bone. (a) ROI selection of medial and lateral tibia subchondral trabecular bone; (b) Diaphragmatic image of medial and lateral tibia subchondral trabecular bone of DH and BS2 guinea pig at age of 3 months. Osteoarthritis and Cartilage 2013 21, 574-581DOI: (10.1016/j.joca.2013.01.002) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Diaphragmatic histological image of tibial end of knee joints of BS2 and DH guinea pigs at age of 1 month. (a) Diaphragmatic image of pore area at osteochondral junction (black arrow) and subchondral trabecular bone area of tibial end of knee joints of BS2 and DH guinea pigs at age of 1 month; (b) Quantitative analysis showed significant lower ratio of pore area/total area comparing with BS2 strain at age of 1 and 3 months; (c) Quantitative analysis showed significant higher ratio of bone area/total area comparing with BS2 strain at age of 1 month. Osteoarthritis and Cartilage 2013 21, 574-581DOI: (10.1016/j.joca.2013.01.002) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Immunohistochemistry of anti-Osterix at osteochondral junction of BS2 and DH guinea pigs. (a) Diaphragmatic image showed positive stained cells of BS2 and DH guinea pigs at age of 3 months; (b) Histomorphometry showed significant larger number of positive stained cells of anti-Osterix per mm2 in DH group than BS2 group at age of 1, 2 and 3 months. Osteoarthritis and Cartilage 2013 21, 574-581DOI: (10.1016/j.joca.2013.01.002) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions