C3 Glomerulonephritis Associated With Complement Factor B Mutation Sanjeev Sethi, MD, PhD, Richard J.H. Smith, MD, John J. Dillon, MD, Fernando C. Fervenza, MD, PhD  American Journal of Kidney Diseases  Volume 65, Issue 3, Pages 520-521 (March 2015) DOI: 10.1053/j.ajkd.2014.10.023 Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 (A-C) Light microscopy shows membranoproliferative glomerulonephritis with increased mesangial cellularity, segmental endocapillary proliferation, double-contour formation along the capillary loops, and lobular accentuation of the glomerular tufts (A: Mason trichrome stain; original magnification, ×20; B: periodic acid–Schiff stain; original magnification, ×40; C: silver methenamine stain; original magnification, ×40). The interstitium was well preserved. Immunofluorescence microscopy (not shown) showed bright staining for C3 (3+), undetectable staining for immunoglobulin A (IgA) and IgM, and minimal staining for IgG (1+). (D) Electron microscopy showed mesangial and subendothelial deposits (black arrows; original magnification, ×4,800). American Journal of Kidney Diseases 2015 65, 520-521DOI: (10.1053/j.ajkd.2014.10.023) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions