Volume 379, Issue 9812, Pages (January 2012)

Slides:

Advertisements

Similar presentations

HIVNET 023 Sponsored by the US National Institute of Allergy and Infectious Diseases, National Institute of Health through the HIV Prevention Trials Network.

Advertisements

Diabetes Management in Long-Term Care: An Exploratory Study of the Current Practices and Processes to Managing Frail Elderly Persons with Type 2 Diabetes.

Crohn's disease Prof Daniel C Baumgart, MD, Prof William J Sandborn, MD The Lancet Volume 380, Issue 9853, Pages (November 2012) DOI: /S (12)

Volume 387, Issue 10037, Pages (June 2016)

Volume 370, Issue 9586, Pages (August 2007)

Volume 355, Issue 9206, Pages (March 2000)

Volume 386, Issue 9990, Pages (July 2015)

Volume 357, Issue 9273, Pages (June 2001)

Volume 364, Issue 9440, Pages (September 2004)

Volume 367, Issue 9517, Pages (April 2006)

Volume 357, Issue 9257, Pages (March 2001)

Volume 370, Issue 9601, Pages (November 2007)

Volume 378, Issue 9785, Pages (July 2011)

Year-round influenza immunisation during pregnancy in Nepal: a phase 4, randomised, placebo-controlled trial Prof Mark C Steinhoff, MD, Prof Joanne Katz,

Long-term effects of hormone replacement therapy

Volume 372, Issue 9633, Pages (July 2008)

Paediatric HIV-1 infection

Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial

Volume 5, Issue 4, Pages (April 2006)

Volume 389, Issue 10076, Pages (April 2017)

Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation.

Volume 371, Issue 9611, Pages (February 2008)

Volume 372, Issue 9633, Pages (July 2008)

Long-term effects of hormone replacement therapy

Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial

Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled.

Volume 1, Issue 3, Pages (August 2014)

Pneumococcal conjugate vaccine 13 delivered as one primary and one booster dose (1 + 1) compared with two primary doses and a booster (2 + 1) in UK infants:

A Randomized, Double-Blind, Placebo-Controlled Trial of Nutritional Supplementation During Acute Illness Salah Gariballa, MD, Sarah Forster, MSc, Stephen.

Volume 377, Issue 9759, Pages (January 2011)

Volume 372, Issue 9642, Pages (September 2008)

Volume 374, Issue 9707, Pages (December 2009)

Patient and Graft Survival Following Kidney Transplantation in Recipients With Cystinosis: A Cohort Study Rebecca A. Spicer, MBChB, Philip A. Clayton,

Volume 2, Issue 6, Pages (June 2015)

Volume 9, Issue 10, Pages (October 2008)

Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled.

Volume 375, Issue 9732, Pages (June 2010)

Resuscitation at birth and cognition at 8 years of age: a cohort study

Volume 385, Issue 9969, Pages (February 2015)

Volume 379, Issue 9821, Pages (March 2012)

Volume 379, Issue 9812, Pages (January 2012)

Volume 384, Issue 9944, Pages (August 2014)

Volume 378, Issue 9785, Pages (July 2011)

Volume 389, Issue 10065, Pages (January 2017)

Volume 16, Issue 1, Pages (January 2017)

Volume 26, Issue 1, Pages (February 2010)

Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double- blind, parallel-group, placebo-controlled trial Dr Andrew R Goudie,

Volume 13, Issue 5, Pages (May 2012)

Volume 376, Issue 9749, Pages (October 2010)

Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled,

Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial

A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled,

The effect of a conditional cash transfer on HIV incidence in young women in rural South Africa (HPTN 068): a phase 3, randomised controlled trial Dr.

Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial

Volume 371, Issue 9627, Pages (May 2008)

Volume 5, Issue 4, Pages (April 2018)

Volume 375, Issue 9726, Pages (May 2010)

Primary prophylaxis of cryptococcal disease with fluconazole in HIV-positive Ugandan adults: a double-blind, randomised, placebo-controlled trial Dr.

Volume 375, Issue 9714, Pages (February 2010)

Volume 369, Issue 9567, Pages (March 2007)

Volume 375, Issue 9715, Pages (February 2010)

Effect of co-trimoxazole on mortality in HIV-exposed but uninfected children in Botswana (the Mpepu Study): a double-blind, randomised, placebo-controlled.

Volume 372, Issue 9632, Pages (July 2008)

Volume 5, Issue 1, Pages (January 2018)

Volume 383, Issue 9930, Pages (May 2014)

Volume 373, Issue 9680, Pages (June 2009)

Clinic attendance and disengagement of young adults with type 1 diabetes after transition of care from paediatric to adult services (TrACeD): a randomised,

Volume 371, Issue 9611, Pages (February 2008)

Volume 18, Issue 6, Pages (June 2019)

Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials Andrew Clark, PhD, Kevin van Zandvoort,

Presentation transcript:

Volume 379, Issue 9812, Pages 221-228 (January 2012) Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial Prof Hoosen M Coovadia, MD, Elizabeth R Brown, ScD, Mary Glenn Fowler, Tsungai Chipato, MBChB, Dhayendre Moodley, PhD, Karim Manji, MBBS, Philippa Musoke, MBChB, Lynda Stranix-Chibanda, MBChB, Vani Chetty, BTech, Wafaie Fawzi, MD, Clemensia Nakabiito, MBChB, Lindiwe Msweli, BA, Roderick Kisenge, MMed, Laura Guay, MD, Anthony Mwatha, MS, Diana J Lynn, BA, Susan H Eshleman, MD, Paul Richardson, MSc, Kathleen George, MPH, Philip Andrew, RN, Lynne M Mofenson, MD, Sheryl Zwerski, CRNP, Yvonne Maldonado, MD The Lancet Volume 379, Issue 9812, Pages 221-228 (January 2012) DOI: 10.1016/S0140-6736(11)61653-X Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile *Only main cause is listed. †Two first-born twins not eligible, one congenital heart defect, one mother in accident, two poor adherence to study procedures, and one mother could not dose competently. The Lancet 2012 379, 221-228DOI: (10.1016/S0140-6736(11)61653-X) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 2 Kaplan-Meier analysis of breastfeeding duration, by study group The Lancet 2012 379, 221-228DOI: (10.1016/S0140-6736(11)61653-X) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 3 Kaplan-Meier analysis of cumulative rates of HIV-1 infection, by study group The Lancet 2012 379, 221-228DOI: (10.1016/S0140-6736(11)61653-X) Copyright © 2012 Elsevier Ltd Terms and Conditions