Etiologies and Outcomes of Acute Liver Failure in Germany

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Presentation transcript:

Etiologies and Outcomes of Acute Liver Failure in Germany Johannes Hadem, Frank Tacke, Tony Bruns, Julia Langgartner, Pavel Strnad, Gerald U. Denk, Panagiotis Fikatas, Michael P. Manns, Wolf P. Hofmann, Guido Gerken, Frank Grünhage, Andreas Umgelter, Christian Trautwein, Ali Canbay Clinical Gastroenterology and Hepatology Volume 10, Issue 6, Pages 664-669.e2 (June 2012) DOI: 10.1016/j.cgh.2012.02.016 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Causative etiologies and outcomes in ALF. Etiology and outcome of 109 patients with primary ALF. Patients who developed ALF due to >1 causative agent appear in >1 bar of the diagram. ACM, acetaminophen. Clinical Gastroenterology and Hepatology 2012 10, 664-669.e2DOI: (10.1016/j.cgh.2012.02.016) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 Outcome analysis of ALF patients. Clinical Gastroenterology and Hepatology 2012 10, 664-669.e2DOI: (10.1016/j.cgh.2012.02.016) Copyright © 2012 AGA Institute Terms and Conditions

Figure 3 Prediction of emergency liver transplantation and/or death by different prognostic models. Kaplan–Meier survival curve analysis of 109 patients with primary ALF comparing those who meet with those who do not meet (A) KCC, (B) MELD score, and (C) BiLE score. (D) ROC curve analysis to evaluate prognostic accuracy of KCC, MELD, and BiLE. AUC (confidence intervals) were 0.777 (0.652–0.901) for BiLE, 0.707 (0.570–0.844) for MELD, and 0.583 (0.436–0.731) for KCC, respectively. Clinical Gastroenterology and Hepatology 2012 10, 664-669.e2DOI: (10.1016/j.cgh.2012.02.016) Copyright © 2012 AGA Institute Terms and Conditions

Supplementary Figure 1 Enrollment of study patients. Clinical Gastroenterology and Hepatology 2012 10, 664-669.e2DOI: (10.1016/j.cgh.2012.02.016) Copyright © 2012 AGA Institute Terms and Conditions

Supplementary Figure 2 Frequency of extrahepatic organ failure in 46 patients with sALI and 109 patients with ALF. Clinical Gastroenterology and Hepatology 2012 10, 664-669.e2DOI: (10.1016/j.cgh.2012.02.016) Copyright © 2012 AGA Institute Terms and Conditions