The variability of regional airflow obstruction within the lungs of patients with asthma: Assessment with hyperpolarized helium-3 magnetic resonance imaging

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Presentation transcript:

The variability of regional airflow obstruction within the lungs of patients with asthma: Assessment with hyperpolarized helium-3 magnetic resonance imaging Eduard E. de Lange, MD, Talissa A. Altes, MD, James T. Patrie, MS, Jaywant Parmar, MD, James R. Brookeman, PhD, John P. Mugler, PhD, Thomas A.E. Platts-Mills, MD, PhD Journal of Allergy and Clinical Immunology Volume 119, Issue 5, Pages 1072-1078 (May 2007) DOI: 10.1016/j.jaci.2006.12.659 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Patient 3. Premethacholine (left) and postmethacholine (right) images from day 1 are on top and from day 2 (97 days later) at the bottom. All images are at the same anatomic level. No ventilation defects exist at baseline at this slice position on both days. Multiple defects (arrows) developed after methacholine was given, with many in the same location on both days (several indicated by arrows). Journal of Allergy and Clinical Immunology 2007 119, 1072-1078DOI: (10.1016/j.jaci.2006.12.659) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Patient 5. Premethacholine (left) and postmethacholine (right) images from day 1 are on top and from day 2 (17 days later) at bottom. Two defects in the same location are observed in the left lung at baseline on both days. On day 1, the one large defect resolved (curved arrow) after methacholine, another decreased (straight arrow), and small new defects developed (one marked by arrowhead). On day 2, the two defects in the left lung remained unchanged after methacholine. A large new defect (short thick arrow) developed on the right and a small defect (open arrow) occurred close to the one marked by the arrowhead on day 1. Journal of Allergy and Clinical Immunology 2007 119, 1072-1078DOI: (10.1016/j.jaci.2006.12.659) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions