Positron emission tomography with 18F-FDG in osteoarthritic knee

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Positron emission tomography with 18F-FDG in osteoarthritic knee H. Nakamura, M.D., Ph.D., K. Masuko, M.D., Ph.D., K. Yudoh, M.D., Ph.D., T. Kato, M.D., Ph.D., K. Nishioka, M.D., Ph.D., T. Sugihara, M.D., Ph.D., M. Beppu, M.D., Ph.D. Osteoarthritis and Cartilage Volume 15, Issue 6, Pages 673-681 (June 2007) DOI: 10.1016/j.joca.2006.12.010 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative coronal (A,D) and axial (B,C,E) sections of PET images in a knee with OA (A–C) and in a control knee (D,E). 18F-FDG uptake was emphasized by sequential colorization ranging from red (high) to blue (low) (C). 18F-FDG commonly accumulated in the periarticular region and was lacking in the articular cartilage. M: medial, L: lateral. Osteoarthritis and Cartilage 2007 15, 673-681DOI: (10.1016/j.joca.2006.12.010) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 The SUVs of whole knees were assessed using 3D data (A,B). Both peak (C) and mean (D) SUVs were significantly higher in OA than in controls. The data were expressed as the mean and standard deviation, and compared using Student's t-test. *P<0.01. Osteoarthritis and Cartilage 2007 15, 673-681DOI: (10.1016/j.joca.2006.12.010) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 SUVs at the joint level were compared between the medial condyle and the lateral condyle (A,B). SUVs of the medial condyle were higher than those of the lateral condyle (C). The data were expressed as the mean and standard deviation, and compared using a paired t-test. *P<0.05. Osteoarthritis and Cartilage 2007 15, 673-681DOI: (10.1016/j.joca.2006.12.010) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 18F-FDG accumulation was found around medial osteophyte (Arrow). (A) Fusion image, (B) MRI, (C) PET axial view, and (D) PET coronal view. Osteoarthritis and Cartilage 2007 15, 673-681DOI: (10.1016/j.joca.2006.12.010) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 18F-FDG accumulation extended along PCL (Arrow). (A) Fusion image, (B) MRI, (C) PET axial view, and (D) PET coronal view. Osteoarthritis and Cartilage 2007 15, 673-681DOI: (10.1016/j.joca.2006.12.010) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 18F-FDG accumulated in the subchondral lesion of the base of the osteophytes. MRI study suggested the lesion as bone edema. (A) Fusion image, (B) proton density-weighted MRI, (C) fat-suppressed MRI, (D) PET axial view, and (E) PET coronal view. Osteoarthritis and Cartilage 2007 15, 673-681DOI: (10.1016/j.joca.2006.12.010) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 7 18F-FDG uptake was found in the bone marrow, spreading out into the medial soft tissue that was speculated to be synovium or ligament. (A) Fusion image, (B) proton density-weighted MRI, (C) fat-suppressed MRI, (D) PET axial view, and (E) PET coronal view. Osteoarthritis and Cartilage 2007 15, 673-681DOI: (10.1016/j.joca.2006.12.010) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions