Gastrointestinal Pathology 2

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Presentation transcript:

Gastrointestinal Pathology 2 Kristine Krafts, M.D.

GI Pathology Outline Esophagus Stomach Intestine Liver Gallbladder Pancreas

GI Pathology Outline Esophagus Stomach Intestine Diverticulosis Inflammatory bowel disease Carcinoma

Diverticulosis Mucosa/submucosa herniates through muscle wall Older patients, low fiber diet Sigmoid colon Asymptomatic unless infected (“diverticulitis”)

Diverticulosis

Diverticulosis

Inflammatory Bowel Disease Crohn Disease Anywhere Patchy Transmural Poor response to surgery Increased risk of cancer Ulcerative Colitis Colon only Continuous Superficial Good response to surgery Increased risk of cancer

Crohn disease Ulcerative colitis

Adenoma Common! 50% of people >60. Benign glands; may become dysplastic More dangerous when: Large (>1 cm) Villous architecture Severely dysplastic

Tubular adenoma of colon

Villous adenoma of colon

Dysplastic (L) vs. normal (R) epithelium

Colon Carcinoma Almost always arises in adenomatous polyp Diet: low fiber, high fat, lots of refined carbs Symptoms: silent for years fatigue, weakness, iron-deficiency anemia occult bleeding, crampy pain 5 year prognosis: 4% (stage 4) - 90% (stage 1)

Colon carcinoma

Colon carcinoma