Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data Lara M.

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Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data Lara M. Hochfeld, Andreas Keller, Thomas Anhalt, Nadine Fricker, Markus M. Nöthen, Stefanie Heilmann-Heimbach Journal of Investigative Dermatology Volume 139, Issue 1, Pages 235-238 (January 2019) DOI: 10.1016/j.jid.2018.06.182 Copyright © 2018 The Authors Terms and Conditions

Figure 1 Volcano plots of the results of the differential microRNA (miRNA) and mRNA expression analyses. Each dot represents either (a) a plucked hair follicle (pHF) expressed mature miRNA (n = 823) or (b) a pHF expressed mRNA gene (n = 15,844). Differentially expressed genes at PWMW < 0.05 are depicted in blue (frontal < occipital) and red (frontal > occipital). Arrows indicate up- (↑) or downregulation (↓) in frontal (F) tissue. Frontal upregulation was observed for 19 miRNAs and 1,915 mRNAs. Frontal downregulation was observed for 124 miRNAs and 921 mRNAs. Numbers in brackets denote the number of miRNAs and mRNAs that showed significant differential expression after the Benjamini-Hochberg correction for multiple testing (PBH < 0.05). Journal of Investigative Dermatology 2019 139, 235-238DOI: (10.1016/j.jid.2018.06.182) Copyright © 2018 The Authors Terms and Conditions

Figure 2 Integration of results of the present differential miRNA and mRNA expression profiling with previous AGA genetic association data. Circular plot showing the results of the integration of data on pHF miRNA (blue, outer circle) and mRNA (red, middle circle) differential expression with AGA genetic association data (green, inner circle) (Hagenaars et al., 2017; Heilmann-Heimbach et al., 2017). The analysis implicated seven genomic regions (PPerm < 0.1) on chromosomes 3q22.2, 6p21.1, 11q12.2, 19q13.33, 20p13, 20q13.33, and 22q11.21. Six of these regions constitute previously unreported candidate regions for AGA. **PPerm ≤ 0.01, §previously reported risk locus (P < 5 × 10–8, Hagenaars et al., 2017). AGA, androgenetic alopecia; miRNA, microRNA; pHF, plucked hair follicle. Journal of Investigative Dermatology 2019 139, 235-238DOI: (10.1016/j.jid.2018.06.182) Copyright © 2018 The Authors Terms and Conditions