Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimüllerian hormone–stratified, dose–response trial in women undergoing.

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Presentation transcript:

Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimüllerian hormone–stratified, dose–response trial in women undergoing in vitro fertilization/intracytoplasmic sperm injection Joan-Carles Arce, M.D., Ph.D., Anders Nyboe Andersen, M.D., Ph.D., Manuel Fernández-Sánchez, M.D., Ph.D., Hana Visnova, M.D., Ph.D., Ernesto Bosch, M.D., Ph.D., Juan Antonio García-Velasco, M.D., Ph.D., Pedro Barri, M.D., Ph.D., Petra de Sutter, M.D., Ph.D., Bjarke M. Klein, Ph.D., Bart C.J.M. Fauser, M.D., Ph.D. Fertility and Sterility Volume 102, Issue 6, Pages 1633-1640.e5 (December 2014) DOI: 10.1016/j.fertnstert.2014.08.013 Copyright © 2014 The Authors Terms and Conditions

Figure 1 (A) Mean number of oocytes retrieved for patients in the five rhFSH dose groups, overall and by AMH stratum. The vertical bars represent standard errors. P values reflect the dose–response relationship. (B, C) Relative proportions of patients with different categories of number of oocytes retrieved by rhFSH dose group and AMH stratum (B, high AMH; C, low AMH). Fertility and Sterility 2014 102, 1633-1640.e5DOI: (10.1016/j.fertnstert.2014.08.013) Copyright © 2014 The Authors Terms and Conditions

Figure 2 Mean rate of blastocysts to oocytes retrieved for patients in the five rhFSH dose groups, (A) overall and by (B) AMH stratum. The vertical bars represent standard errors. P values reflect the dose–response relationship. Fertility and Sterility 2014 102, 1633-1640.e5DOI: (10.1016/j.fertnstert.2014.08.013) Copyright © 2014 The Authors Terms and Conditions

Figure 3 Number of oocytes retrieved and blastocysts by rhFSH dose group (A, high AHM; B, low AMH). The vertical bars represent standard errors. P values reflect the dose–response relationship. ∗ P<.05 vs. other dose groups combined. Fertility and Sterility 2014 102, 1633-1640.e5DOI: (10.1016/j.fertnstert.2014.08.013) Copyright © 2014 The Authors Terms and Conditions

Supplemental Figure 1 Assignment, treatment, and analysis of patients. ITT = intention to treat. Fertility and Sterility 2014 102, 1633-1640.e5DOI: (10.1016/j.fertnstert.2014.08.013) Copyright © 2014 The Authors Terms and Conditions

Supplemental Figure 2 Distribution of initial AMH levels in the whole trial population. Fertility and Sterility 2014 102, 1633-1640.e5DOI: (10.1016/j.fertnstert.2014.08.013) Copyright © 2014 The Authors Terms and Conditions

Supplemental Figure 3 (A, B) Oocytes retrieved, metaphase II (MII) oocytes, and blastocysts by rhFSH dose group for the patients inseminated by ICSI (A, high AMH; B, low AMH). (C, D) Mean rate of blastocysts to MII oocytes for the ICSI patients (C, high AMH; D, low AMH). The vertical bars represent standard errors. P values reflect the dose–response relationship. Fertility and Sterility 2014 102, 1633-1640.e5DOI: (10.1016/j.fertnstert.2014.08.013) Copyright © 2014 The Authors Terms and Conditions