The effects of normothermic and hypothermic cardiopulmonary bypass on defibrillation energy requirements and transmyocardial impedance David Martin,

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Presentation transcript:

The effects of normothermic and hypothermic cardiopulmonary bypass on defibrillation energy requirements and transmyocardial impedance David Martin, MBBS, MRCPa, Jose Garcia, MDb c, C.Robert Valeri, MDd, Shukri F. Khuri, MDb c, Mheir Doursounian, BS The Journal of Thoracic and Cardiovascular Surgery Volume 109, Issue 5, Pages 981-988 (May 1995) DOI: 10.1016/S0022-5223(95)70324-1 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Sample family of dose-response curves derived from single hypothermic (group 1) experiment. Circles denote measurements made immediately after establishment of CPB; triangles and squares denote repeated dose-response measurements made after 1 and 2 hours of CPB, respectively. Note that abscissa scale is logarithmic. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 981-988DOI: (10.1016/S0022-5223(95)70324-1) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Graph showing defibrillation energy requirements (E50 ) immediately after CPB is established (T0 ), after 1 hour (T1 ), and after 2 hours (T2 ). Hatched bars denote hypothermic (group 1) experiments; open bars denote normothermic (group 2) experiments. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 981-988DOI: (10.1016/S0022-5223(95)70324-1) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Graph of pooled impedance data expressed as percentage of impedance at beginning of T0 defibrillation dose-response curve generation plotted for beginning and end of each series of inductions of ventricular fibrillation. Closed circles denote hypothermic (group 1) experiments; open circles denote normothermic (group 2) experiments. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 981-988DOI: (10.1016/S0022-5223(95)70324-1) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 Graph showing changes in extracellular intramyocardial pH during 2 hours of CPB. Symbols are as in Fig. 2. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 981-988DOI: (10.1016/S0022-5223(95)70324-1) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 5 Graph showing changes in heart rate during 2 hours of CPB. Symbols are as in Fig. 2. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 981-988DOI: (10.1016/S0022-5223(95)70324-1) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 6 Graph showing changes in LVEDP during 2 hours of CPB. Symbols are as in Fig. 2. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 981-988DOI: (10.1016/S0022-5223(95)70324-1) Copyright © 1995 Mosby, Inc. Terms and Conditions