Effect of altered 3′UTR on miRNA-mediated gene regulation.

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Effect of altered 3′UTR on miRNA-mediated gene regulation. Effect of altered 3′UTR on miRNA-mediated gene regulation. (A) Schematic describing the location of miRNA binding sites with respect to the proximal and distal polyadenylation events. (B) The miRNA binding sites that were predicted to be associated with stitched transcripts across different transcriptomes. (C) The distribution of miRNA binding sites on the transcripts at the regions spanning the proximal and distal polyadenylation sites. (D) The bar plot shows the number of the degradome tags mapped to the transcripts on either the proximal (positive y-axis) or distal (negative y-axis) polyadenylation site. miRNA, microRNA; UTR, untranslated region. Vairavan Lakshmanan et al. G3 2016;6:3035-3048 ©2016 by Genetics Society of America