Responsiveness to metformin in girls with androgen excess: collective influence of genetic polymorphisms Marta Díaz, Ph.D., Abel López-Bermejo, M.D.,

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Responsiveness to metformin in girls with androgen excess: collective influence of genetic polymorphisms Marta Díaz, Ph.D., Abel López-Bermejo, M.D., David Sánchez-Infantes, Ph.D., Judit Bassols, Ph.D., Francis de Zegher, M.D., Ph.D., Lourdes Ibáñez, M.D., Ph.D. Fertility and Sterility Volume 96, Issue 1, Pages 208-213.e2 (July 2011) DOI: 10.1016/j.fertnstert.2011.04.075 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Selection of changes after 1 year of metformin therapy in 104 girls with androgen excess after precocious pubarche. Girls are grouped by genetic score (from 1 to 4, see Materials and Methods) for increasing responsiveness to metformin. P values are from repeated-measures general linear model (adjusted for age and body mass index [BMI] at start of metformin therapy). Fertility and Sterility 2011 96, 208-213.e2DOI: (10.1016/j.fertnstert.2011.04.075) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions