Volume 98, Issue 1, Pages 1-4 (July 1999)

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Volume 98, Issue 1, Pages 1-4 (July 1999) Fundamentally Different Logic of Gene Regulation in Eukaryotes and Prokaryotes Kevin Struhl Cell Volume 98, Issue 1, Pages 1-4 (July 1999) DOI: 10.1016/S0092-8674(00)80599-1 Copyright © 1999 Cell Press Terms and Conditions

Figure 1 Transcriptional States in Prokaryotes and Eukaryotes Activators (A) and repressors (R) interact respectively with enhancer (ENH) or operator (OP) sequences and affect transcription by prokaryotic RNA polymerase (RNAP) or the eukaryotic Pol II machinery (TFIID + Pol II holoenzyme). In eukaryotes, recruitment of chromatin modifying activities by activators or repressors leads to altered chromatin structure (depicted by color or DNA within nucleosomes). See text for details. Cell 1999 98, 1-4DOI: (10.1016/S0092-8674(00)80599-1) Copyright © 1999 Cell Press Terms and Conditions

Figure 2 Hypothetical Intermediate States of Eukaryotic Transcription for a Given Promoter Activator A binds to unmodified nucleosomal templates, leading to successive recruitment of chromatin modifying activities and the creation of an extended domain of active chromatin structure that permits binding of activator B and subsequent recruitment of the Pol II machinery. Binding of activator A is transient, but the recruited chromatin modifying activities remain stably associated for extended times. The existence, order, and stability of the indicated states can be developmentally regulated, but will vary according to the specific promoter. Cell 1999 98, 1-4DOI: (10.1016/S0092-8674(00)80599-1) Copyright © 1999 Cell Press Terms and Conditions