Polycystic ovary syndrome: an ancient disorder?

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Presentation transcript:

Polycystic ovary syndrome: an ancient disorder? Ricardo Azziz, M.D., M.P.H., M.B.A., Daniel A. Dumesic, M.D., Mark O. Goodarzi, M.D., Ph.D. Fertility and Sterility Volume 95, Issue 5, Pages 1544-1548 (April 2011) DOI: 10.1016/j.fertnstert.2010.09.032 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Hypothetical BMI-fecundity relationship in PCOS. Fertility and Sterility 2011 95, 1544-1548DOI: (10.1016/j.fertnstert.2010.09.032) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Effect of time on linkage disequilibrium. Both LD plots represent a 100-kB area centered around the microsatellite D19S884 (location approximately indicated by black arrows), a marker for which one allele has been associated with PCOS in multiple studies (37). The data were downloaded from the International HapMap Project (Phase II+III, Release 27, http://hapmap.ncbi.nlm.nih.gov); plots were generated using Haploview (ver. 4.2, http://www.broadinstitute.org/mpg/haploview). The top LD plot is from Yoruba subjects from Ibadan, Nigeria (YRI), and the bottom panel is that of the Utah residents with ancestry from northern and western Europe (CEU). The LD plots display D’ values for each pair of single nucleotide polymorphisms (SNPs) in the box at the intersection of the diagonals from each SNP. The darker boxes indicate greater degrees of LD for the corresponding pair of variants. Triangles around boxes indicate haplotype blocks determined by the confidence intervals algorithm in Haploview. The older Yoruba population exhibits less extensive LD and smaller haplotype blocks. Fertility and Sterility 2011 95, 1544-1548DOI: (10.1016/j.fertnstert.2010.09.032) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions