B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion Rambod Amirnovin, MD, Roberta.

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Presentation transcript:

B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion Rambod Amirnovin, MD, Roberta L. Keller, MD, Christina Herrera, BA, Jong-Hau Hsu, MD, Sanjeev Datar, MD, PhD, Tom R. Karl, MD, Ian Adatia, MBChB, Peter Oishi, MD, Jeffrey R. Fineman, MD The Journal of Thoracic and Cardiovascular Surgery Volume 145, Issue 5, Pages 1279-1287 (May 2013) DOI: 10.1016/j.jtcvs.2012.07.067 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Comparison of B-type natriuretic peptide (BNP) before and after cardiopulmonary bypass in all 4 diagnostic groups. NORW, Norwood procedure (univentricular heart); TGA, d-transposition of the great arteries; LRS, left to right shunt; TOF, tetralogy of Fallot. Data presented as mean ± SD. Analysis of variance analysis within all groups, P < .01. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1279-1287DOI: (10.1016/j.jtcvs.2012.07.067) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Group I (univentricular heart [UVH]). Comparisons of changes in, Left, absolute B-type natriuretic peptide (BNP) levels and, Right, postoperative/preoperative (post/pre) BNP ratios over time between patients with good outcomes (n = 20) and patients with poor outcomes (n = 4). Both absolute and ratios of BNP were greater at 12 and 24 hours after cardiopulmonary bypass in poor outcome group. Data presented as mean ± SD. ∗P < .05 vs good outcome (Student t test). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1279-1287DOI: (10.1016/j.jtcvs.2012.07.067) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Group III (left to right shunt [LRS]). Comparisons of changes in, Left, absolute B-type natriuretic peptide (BNP) levels and, Right, postoperative/preoperative (post/pre) BNP ratios over time between patients with good outcomes (n = 53) and patients with poor outcomes (n = 2). Both absolute and ratios of BNP were greater at 12 and 24 hours after cardiopulmonary bypass in poor outcome group. Data presented as mean ± SD. ∗P < .05 vs good outcome (Student t test). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1279-1287DOI: (10.1016/j.jtcvs.2012.07.067) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Group IV (tetralogy of Fallot [TOF]). Comparisons of changes in, left, absolute B-type natriuretic peptide (BNP) levels and, right, postoperative/preoperative (post/pre) BNP ratios over time between patients with good outcomes (n = 22) and patients with poor outcomes (n = 3). Both absolute values and ratios of BNP were greater at 12 and 24 hours after cardiopulmonary bypass in poor outcome group. Data presented as mean ± SD. ∗P < .05 vs good outcome (Student t test). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 1279-1287DOI: (10.1016/j.jtcvs.2012.07.067) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions