MRSA virulence proteins cause LMC death and diminished CLV function

Slides:

Advertisements

Similar presentations

Fig. 1 CSF1 is increased in blood of melanoma patients and correlates with disease progression. CSF1 is increased in blood of melanoma patients and correlates.

Advertisements

Fig. 6. Transgenic expression of αLNNd and mag in dyW/dyW mice improves muscle function, increases body weight, and prolongs life span. Transgenic expression.

Fig. 4. PVSRIPO infection of DCs is sublethal, is marginally productive, and induces sustained proinflammatory cytokine production. PVSRIPO infection of.

Fig. 7. Downstream effects of α-synuclein on mitochondria.

Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.

Fig. 5. Blocking LTB4 during initial lymphangiogenesis period abrogates the therapeutic benefit of LTB4 antagonism. Blocking LTB4 during initial lymphangiogenesis.

Transfer of miR-223 during neutrophil-epithelial cell interactions

Fig. 5. Circulating PPi concentration does not correlate with severity of calcification phenotype in mice. Circulating PPi concentration does not correlate.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain.

Fig. 7. Role of PDE5 up-regulation in lung cancer–associated PH.

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

Fig. 3. Thorase variants increase the frequency and amplitude of sEPSCs and mEPSCs. Thorase variants increase the frequency and amplitude of sEPSCs and.

Fig. 1. BCAS1 expression identifies newly generated oligodendrocytes.

Fig. 3. LTB4 exhibits concentration-dependent effects on HLEC lymphangiogenesis and survival. LTB4 exhibits concentration-dependent effects on HLEC lymphangiogenesis.

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Fig. 4. Biomechanical properties of treated tibiae.

Fig. 5. Prophylactic treatment with GS-5734 reduces SARS-CoV disease.

Analysis of brain and spinal cord of treated Gaa−/− mice and controls

Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.

Fig. 3. A circadian rhythm in fibroblast wound-healing response.

PVSRIPO-mediated APC activation occurs in immunosuppressive conditions

Fig. 1 MT-2 ameliorates asthmatic pulmonary resistance.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 1. IS mediates a hyperthrombotic uremic phenotype in an AHR-dependent manner across CKD stages. IS mediates a hyperthrombotic uremic phenotype in.

Fig. 3 Biological function of TG2 and the interaction with MT-2.

Fig. 5. Remnants of PS+ platelets induce neutrophil macroaggregation.

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Fig. 7 pDCs are critical for the maintenance of skin fibrosis and for the presence of CXCL4 in the skin. pDCs are critical for the maintenance of skin.

Fig. 6. Apoptotic MSCs exert in vivo immunosuppression in a TH2-type inflammation model in the absence of cytotoxic cells. Apoptotic MSCs exert in vivo.

Fig. 8 TLR8 exacerbates disease in the BLM-induced fibrosis model.

Fig. 6 pDCs infiltrate the skin of BLM-treated mice, and their depletion attenuates skin fibrosis. pDCs infiltrate the skin of BLM-treated mice, and their.

Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs.

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

Fig. 7 BRD0705 impairs colony formation in AML cell lines and patient cells and shows in vivo efficacy in multiple AML mouse models. BRD0705 impairs colony.

Fig. 5 CXCL4 potentiates TLR9-mediated activation but has minimal effect on TLR7-mediated activation of pDCs purified from SSc or HDs. CXCL4 potentiates.

Fig. 7. Inhibitory mechanisms of C12G6.

Fig. 5 Local gel scaffold for T cell memory response.

Fig. 4 Whisker deprivation–induced remapping is stable beyond the deprivation period. Whisker deprivation–induced remapping is stable beyond the deprivation.

Fig. 3. ERRα is involved in the regulation of OPLAH.

Fig. 2 Fas controls IL-1RA–sEV secretion in murine MSCs.

Fig. 1 BX795 suppresses HSV-1 infection.

Fig. 7 Improvement of clinical score and axon pathology by nasal IL-4 treatment during chronic EAE. Improvement of clinical score and axon pathology by.

Fig. 4. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model of ALS. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model.

Comparison of therapeutic efficacies of C12G6 and other bnAbs in mice

Fig. 7 DMN-Tre labeling of Mycobacterium tuberculosis is inhibited by tuberculosis drug cocktail, unlike auramine staining. DMN-Tre labeling of Mycobacterium.

Fig. 2. IL-2/rapamycin–expanded T cells express homing receptors to traffic to lymphoma sites and are resistant to SN-38 toxicity. IL-2/rapamycin–expanded.

Fig. 4. Efficacy of C12G6 compared with and in combination with oseltamivir in mice. Efficacy of C12G6 compared with and in combination with oseltamivir.

Fig. 1. Bexarotene promotes PPARδ activation to ameliorate the neurotoxicity of mutant huntingtin. Bexarotene promotes PPARδ activation to ameliorate the.

Fig. 2. Exposure of both TCR and CAR antigens diminishes efficacy of CAR8 but not CAR4 cells. Exposure of both TCR and CAR antigens diminishes efficacy.

Fig. 1 Collecting popliteal lymphatic vessels exhibit diminished contraction and lymph velocity after MRSA infection. Collecting popliteal lymphatic vessels.

Fig. 4. Acute lung injury in miR-223−/y mice.

Fig. 5. Prophylactic and therapeutic efficacy of C12G6 in ferrets.

Fig. 5 DMN-Tre labeling is selective for live mycobacteria.

Decreased weight and adiposity is transmissible via the gut microbiota

Fig. 2. Cellular response to FolamiRs in vitro.

Fig. 1. Specificity of FolamiR uptake in cancer cells in culture.

Fig. 7. Scale-up of AAV vector–mediated liver gene transfer of secretable GAA to nonhuman primates. Scale-up of AAV vector–mediated liver gene transfer.

Fig. 2. Thorase variants cause impaired GluA2 endocytosis and trafficking in mouse primary cortical neurons. Thorase variants cause impaired GluA2 endocytosis.

Effects of embryonic hypoxia on fasted and postprandial cardiac shunting. Effects of embryonic hypoxia on fasted and postprandial cardiac shunting. Mean.

Fig. 4 Labeling of Msmeg with DMN-Tre is fast and specific and depends on Ag85A function. Labeling of Msmeg with DMN-Tre is fast and specific and depends.

Fig. 1. MSCs undergo in vivo apoptosis after infusion without affecting immunosuppression. MSCs undergo in vivo apoptosis after infusion without affecting.

Fig. 3 Biological function of TG2 and the interaction with MT-2.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Fig. 5 C9orf72 knockdown disrupts autophagy induction.

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

Presentation transcript:

Fig. 7 MRSA virulence proteins cause LMC death and diminished CLV function. MRSA virulence proteins cause LMC death and diminished CLV function. (A) mLMC viability analysis after exposure for 24 hours to control medium (TSB), agr mutant–conditioned medium, or MRSA-conditioned medium; n = 3 independent experiments. (B) LDH release from LMCs incubated with conditioned medium from WT or agr mutant MRSA; n = 3 independent experiments. (C) Computer-automated quantification of % αSMA-positive area of PLV in uninfected animals and animals 30 days after agr mutant MRSA infection; n = 3 to 4 mice for each group. (D) Representative traces from lymphatic vessel wall measurements show lymphatic diameter and contraction over time in uninfected mice and mice infected with WT or agr mutant MRSA for 30 days. (E) Ejection fraction shows the strength of lymphatic vessel contraction in uninfected mice and mice infected with WT or agr mutant MRSA for 30 days; n = 8 to 17. (F) Frequency indicates the cpm of lymphatic vessel contractions in uninfected mice and mice infected with WT or agr mutant MRSA for 30 days; n = 8 to 15. For (E) and (F), statistical analysis was performed by one-way ANOVA comparison with Fisher’s least significance difference post hoc analysis. Error bars show SEM. *P < 0.05. Dennis Jones et al., Sci Transl Med 2018;10:eaam7964 Published by AAAS