Signaling Endosomes Trigger Synapse Assembly

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Presentation transcript:

Signaling Endosomes Trigger Synapse Assembly Jason M. Newbern, Xiaoyan Li, William D. Snider Neuron Volume 67, Issue 3, Pages 352-354 (August 2010) DOI: 10.1016/j.neuron.2010.07.025 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 TrkA Signaling Endosomes Trigger Postsynaptic Clustering in Sympathetic Neuron Dendrites Postganglionic sympathetic axons innervate target organs, allowing target-derived NGF to bind TrkA and initiate the retrograde transport of signaling endosomes. Signaling endosomes travel into the postganglionic sympathetic dendrites (blue) and trigger the clustering of postsynaptic components required for synaptic assembly with preganglionic axons (red). PSD clustering requires ERK1/2 signaling within dendrites and is antagonized by signaling downstream of p75. Neuron 2010 67, 352-354DOI: (10.1016/j.neuron.2010.07.025) Copyright © 2010 Elsevier Inc. Terms and Conditions