Bone marrow lesions are associated with altered trabecular morphometry

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Bone marrow lesions are associated with altered trabecular morphometry J.B. Driban, A. Tassinari, G.H. Lo, L.L. Price, E. Schneider, J.A. Lynch, C.B. Eaton, T.E. McAlindon Osteoarthritis and Cartilage Volume 20, Issue 12, Pages 1519-1526 (December 2012) DOI: 10.1016/j.joca.2012.08.013 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Trabecular morphometry was quantified in the subchondral bone of the central medial proximal tibia using high-resolution coronal 3D FISP MR images with ROI [3.75 mm (vertical) × 13.5–17.0 mm (medial–lateral)] located on 20 consecutive slices [(a) most posterior image and (b) most anterior image]. (c & d) To help localize the ROI and BMLs, coronal IW TSE images were registered to the trabecular images, to determine the corresponding slice range of interest (e.g., image a corresponds to image c and image b corresponds to image d). Osteoarthritis and Cartilage 2012 20, 1519-1526DOI: (10.1016/j.joca.2012.08.013) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 (a) Sagittal fat-suppressed IW TSE image were used to determine the presence, location and extent of the BML. Two vertical lines correspond to the locations of most anterior [Fig. 1(c)] and posterior [Fig. 1(d)] coronal slices. The reader identified anterior and posterior borders of the ROI and of the BMLs using the eFILM 3D Cursor tool. (b) Pictorial representation of an axial image, with the ROI's width [medial–lateral] and depth [posterior–anterior] marked. Black line represents the outline of the proximal tibia. The grey irregular shape represents the BML. M = medial; A = anterior. Osteoarthritis and Cartilage 2012 20, 1519-1526DOI: (10.1016/j.joca.2012.08.013) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Box plots demonstrating the distribution of trabecular measures [(a) aBV/TV, (b) aTB.Th, (c) aTB.N, (d) aTB.Sp] in regions with no, small, or large BMLs. The boxes represent the interquartile range of the trabecular measures and the whiskers demonstrate 1.5 times the interquartile range. Data beyond 1.5 times the interquartile range are indicated as small boxes. The horizontal line within the box represents the median while the plus sign defines the mean. Osteoarthritis and Cartilage 2012 20, 1519-1526DOI: (10.1016/j.joca.2012.08.013) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions