Influence of endothelial cell seeding on platelet deposition and patency in small- diameter Dacron arterial grafts Brent T. Allen, M.D., Julie A. Long,

Slides:

Advertisements

Similar presentations

Endothelial cell seeding reduces thrombogenicity of Dacron grafts in humans Per Örtenwall, MD, PhD *, Hans Wadenvik, MD, PhD **, Jack Kutti, MD, PhD **,

Advertisements

Development and regression of intimal thickening of arterially transplanted autologous vein grafts in dogs Kazumasa Morinaga, M.D., Hiroshi Eguchi, M.D.,

Shunya Shindo, M. D. , Atsuhiko Takagi, M. D. , Anthony D

Natural history, duplex characteristics, and histopathologic correlation of arterial injuries in a canine model Thomas F. Panetta, MD, Clifford M. Sales,

Bioengineered vascular access maintains structural integrity in response to arteriovenous flow and repeated needle puncture Bryan W. Tillman, MD, PhD,

Decellularized vein as a potential scaffold for vascular tissue engineering Patrick J Schaner, MD, Niels D Martin, MD, Thomas N Tulenko, PhD, Irving M.

Reconstruction of pulmonary artery with porcine small intestinal submucosa in a lamb surgical model: Viability and growth potential Lorenzo Boni, MD,

Central venous catheter failure is induced by injury and can be prevented by stabilizing the catheter tip Ted R. Kohler, MD, Thomas R. Kirkman, BS Journal.

Vascular anastomoses with laser energy

Development of a “leak-proof,” knitted Dacron vascular prosthesis

Experimental noninferiority trial of synthetic small-caliber biodegradable versus stable vascular grafts Damiano Mugnai, MD, Jean-Christophe Tille, MD,

Lucas P. Neff, MD, Bryan W. Tillman, MD, PhD, Saami K

The role of circulating cells in the healing of vascular prostheses

Vida K. Stark, MS, Thomas F. Warner, MD, John R. Hoch, MD

Vein adaptation to arterialization in an experimental model

Long-term patency of small-diameter vascular graft made from fibroin, a silk-based biodegradable material Soichiro Enomoto, MD, PhD, Makoto Sumi, MD,

Decellularized vein as a potential scaffold for vascular tissue engineering Patrick J Schaner, MD, Niels D Martin, MD, Thomas N Tulenko, PhD, Irving M.

Compound polyglactin 910/polypropylene small vessel prostheses

Makoto Hashizume, M. D. , Ph. D. , Yeng Yang, M. D. , Spencer Galt, M

Chronic in vitro shear stress stimulates endothelial cell retention on prosthetic vascular grafts and reduces subsequent in vivo neointimal thickness

Nitric oxide–releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts Paul S. Fleser, MD, Vijay K. Nuthakki,

Effect of differential shear stress on platelet aggregation, surface thrombosis, and endothelialization of bilateral carotid-femoral grafts in the dog

An “off the shelf” vascular allograft supports angiogenic growth in three-dimensional tissue engineering Johann M. Zdolsek, MD, Wayne A. Morrison, MB.

Mechanisms of arterial graft failure. II

J. A. C. Buckels, M. D. , F. R. C. S. , A. G. Nordestgaard, M. D. , S

Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the.

Favorable scanning electron microscopic findings of stapled saphenous vein–carotid artery anastomoses Mohammad Bashar Izzat, Anthony P.C Yim, MD, Kenny.

Ischemia and activated neutrophils alter coronary microvascular but not epicardial coronary artery reactivity Margit Kadletz, MDa, Rebecca J. Dignan,

Conformational stress and anastomotic hyperplasia

Heat-denatured albumin-coated Dacron vascular grafts: Physical characteristics and in vivo performance MAJ, MC, USA John D. Rumisek, M.D., Charles E.

Vein graft failure Journal of Vascular Surgery

Hiromichi Miwa, MD, Takehisa Matsuda, PhD Journal of Vascular Surgery

The fate of an endothelium layer after preconditioning

Differences in reendothelialization after balloon catheter removal of endothelial cells, superficial endarterectomy, and deep endarterectomy Steven G.

Autologous fibrin-coated small-caliber vascular prostheses improve antithrombogenicity by reducing immunologic response Tomomi Hasegawa, MD, PhD, Kenji.

COMBINED INTERNAL CAROTID AND HYPOGLOSSAL ARTERY ENDARTERECTOMIES IN A SYMPTOM-FREE PATIENT WITH CONTRALATERAL INTERNAL CAROTID ARTERY OCCLUSION Raymond.

Dacron inhibition of arterial regenerative activities

Hydrophilic surface modification of metallic endoluminal stents

Fresh venous allografts in peripheral arterial reconstruction in dogs

Acute platelet deposition after carotid endarterectomy in sheep: Vein patch compared with gelatin-sealed Dacron and polytetrafluoroethylene patch closure

Endothelial cell–lined skeletal muscle ventricles in circulation

Rapid cellular luminal coverage of Dacron inferior vena cava prostheses in dogs by immediate seeding of autogenous endothelial cells derived from omental.

Photodynamic therapy of vein grafts: Suppression of intimal hyperplasia of the vein graft but not the anastomosis Glenn M. LaMuraglia, MD, Michael L.

John Blebea, MD, Robert A. Cambria, MD, David DeFouw, PhD, Richard N

Impact of endothelial cell seeding on long-term patency and subendothelial proliferation in a small-caliber highly porous polytetrafluoroethylene graft

Robert A. McCready, M. D. , Margaret A. Price, B. S. , Richard J

Postoperative duplex scan surveillance of axillofemoral bypass grafts

Mostafa N. El-Sanadiki, MB, MS, K. Simon Cross, MB, John J

Biologic degeneration of vein grafts after thrombotic occlusion: thrombectomy within 3 days results in better indices of viability Shigehisa Kawai, MD,

Robert Guidoin, Ph. D. , Henri-Paul Noël, M. D. , Serge Dubé, M. D

Effects of antiplatelet agents in combination with endothelial cell seeding on small- diameter Dacron vascular graft performance in the canine carotid.

Norman A. Shoenfeld, M. D. , Jens Eldrup-Jorgensen, M. D

The natural history of microsurgical lymphovenous anastomoses: An experimental study Peter Gloviczki, M.D., Larry H. Hollier, M.D., Frederick E. Nora,

Dog peritoneal and pleural cavities as bioreactors to grow autologous vascular grafts Wai-Leng Chue, MBBS, Gordon R Campbell, PhD, Noel Caplice, MBBS,

Endothelial cell harvest for seeding vascular prostheses: The influence of technique on cell function, viability, and number Bernard M. Bourke, M.B.B.S.,

Polyurethane vascular prostheses decreases neointimal formation compared with expanded polytetrafluoroethylene Marc G. Jeschke, MD, Valentin Hermanutz,

External stenting reduces early medial and neointimal thickening in a pig model of arteriovenous bypass grafting Gianni D. Angelini, FRCS, Mohammad Bashar.

Thrombus-free, human endothelial surface in the midregion of a Dacron vascular graft in the splanchnic venous circuit—Observations after nine months of.

Platelet survival and serotonin content after placement of arterial prostheses in dogs: Effects of neointimal coverage and high- and low-dose aspirin

Endothelial seeding of polytetrafluoroethylene femoral popliteal bypasses: The failure of low-density seeding to improve patency Malcolm Herring, MD,

Richard L. Binns, MD Journal of Vascular Surgery

Favorable balance of prostacyclin and thromboxane A2 improves early patency of human in situ vein grafts Harry L. Bush, M.D., John N. Graber, M.D., Joseph.

Experimental colonization of a polyester vascular graft with Staphylococcus aureus: A quantitative and morphologic study Catherine Leport, MD, Olivier.

Endothelial cell seeding of a new PTFE vascular prosthesis

Carotid biaxillary bypass: A new operation

Reduction in deposition of indium 111—labeled platelets after autologous endothelial cell seeding of Dacron aortic bifurcation grafts in humans: A preliminary.

The effects of endothelial injury on smooth muscle cell proliferation

Side-to-side sutureless vascular anastomosis with magnets

William C. Quist, MD, PhD, Frank W. LoGerfo, MD

Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia—A review Alexander W. Clowes, MD, Michael A. Reidy,

Presentation transcript:

Influence of endothelial cell seeding on platelet deposition and patency in small- diameter Dacron arterial grafts Brent T. Allen, M.D., Julie A. Long, M.D., Richard E. Clark, M.D., Gregorio A. Sicard, M.D., Kevin T. Hopkins, B.S., Michael J. Welch, Ph.D. Journal of Vascular Surgery Volume 1, Issue 1, Pages 224-233 (January 1984) DOI: 10.1016/0741-5214(84)90201-5 Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 1 Scanning electron micrograph of luminal surface of a nondistended external jugular vein after endothelial cell harvesting. All but one (arrow) of the endothelial cells were removed, which left a surface composed of collagen and smooth muscle. (×640.) Journal of Vascular Surgery 1984 1, 224-233DOI: (10.1016/0741-5214(84)90201-5) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 2 Scanning electron micrograph of luminal surface of a freshly seeded Dacron graft. A cluster of endothelial cells (arrow) is seen among Dacron fibers, red cells, platelets, and fibrin. (×640.) Journal of Vascular Surgery 1984 1, 224-233DOI: (10.1016/0741-5214(84)90201-5) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 3 Serial indium 111—labeled platelet scintigrams from femoral region of a dog studied at 24 hours, 2 weeks, 1 month, and 2 months postoperatively. Platelet deposition on control grafts (large arrows) decreased from 24 hours to 2 weeks but markedly increased after withdrawal of aspirin therapy. Platelet accumulation on endothelial cell—seeded grafts (small arrows) appeared less than that on controls by 2 weeks and continued to decrease after withdrawal of aspirin therapy. Journal of Vascular Surgery 1984 1, 224-233DOI: (10.1016/0741-5214(84)90201-5) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 4 There was no significant difference between carotid and femoral regions in %InExe for similar grafts (control or seeded). Analysis of %InExe data for each type of graft was performed after results from carotid and femoral regions were combined. Statistical comparisons (p values) between control and seeded grafts at each time interval are indicated above values for n. Journal of Vascular Surgery 1984 1, 224-233DOI: (10.1016/0741-5214(84)90201-5) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 5 Patent control graft (A) explanted at 1 month from right carotid artery (RC) demonstrates white areas of neointimal pannus ingrowth from each anastomosis. Neointima was not complete, however, as demonstrated by a scanning electron micrograph (B) taken from dark midportion (squared area in A) of a control graft, which revealed a surface composed of fibrin red cells and platelet aggregates. An endothelial cell—seeded graft (C) explanted at 3 months from left carotid artery (LC) exhibits a complete neointimal lining. A smooth layer of endothelial cells is seen in a scanning electron micrograph (D) taken from squared area of seeded graft in C. (B and D, Original magnification ×1250.) Journal of Vascular Surgery 1984 1, 224-233DOI: (10.1016/0741-5214(84)90201-5) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 6 A control graft that thrombosed between 2 and 3 months. Blood flow is toward RF. Areas of neointimal pannus ingrowth are indicated by small arrows. Graft occlusion appeared to result from subintimal thickening at distal anastomosis (large arrow). Journal of Vascular Surgery 1984 1, 224-233DOI: (10.1016/0741-5214(84)90201-5) Copyright © 1984 Mosby, Inc. Terms and Conditions