Volume 83, Issue 2, Pages (February 2013)

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Volume 83, Issue 2, Pages 285-292 (February 2013) A family-based association study after genome-wide linkage analysis identified two genetic loci for renal function in a Mongolian population Hansoo Park, Hyun-Jin Kim, Seungbok Lee, Yun Joo Yoo, Young Seok Ju, Jung Eun Lee, Sung-Il Cho, Joohon Sung, Jong-Il Kim, Jeong-Sun Seo Kidney International Volume 83, Issue 2, Pages 285-292 (February 2013) DOI: 10.1038/ki.2012.389 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Multipoint logarithm of odds (LOD) results of the genome-wide linkage scan for estimated glomerular filtration rate. (a) The linkage results of autosomal regions. (b) The linkage peak on chromosome 9, which shows the highest LOD score in this study (LOD=2.8). (c) The linkage peak on chromosome 15, reaching the threshold level for suggestive linkage (LOD>1.9). Kidney International 2013 83, 285-292DOI: (10.1038/ki.2012.389) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 2 Regional association plots and linkage disequilibrium (LD) structures in different ethnicities (YRI: African, CEU: European, and JPT+CHB: Japanese and Chinese) based on HapMap data. The blue diamond indicates the most significant single-nucleotide polymorphism (SNP) of each region, and nearby SNPs are color-coded to show their LD relationships with the top SNP (r2<0.2; white, 0.2≤r2<0.4; yellow, 0.4≤r2<0.8; orange, r2≥0.8; red). Asterisk indicates previously reported SNPs to be associated with estimated glomerular filtration rate.12,13,16 Local LD is reflected by the recombination rates from HapMap data. (a) The association plot near 9q21.32. Green dot is another candidate SNP in FRMD3 that has no LD with our top SNP on chromosome 9. (b) The association plot near 15q21.1. Kidney International 2013 83, 285-292DOI: (10.1038/ki.2012.389) Copyright © 2013 International Society of Nephrology Terms and Conditions