Interleukin-22 Treatment Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration Via Stat3 Activation and Reduces GI Gvhd Caroline A. Lindemans,

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Interleukin-22 Treatment Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration Via Stat3 Activation and Reduces GI Gvhd Caroline A. Lindemans, MD, PhD, Marco Calafiore, PhD, Margaret O'Connor, Anna Mertelsmann, Marcel R.M. van den Brink, MD, PhD, Alan M. Hanash, MD, PhD Biology of Blood and Marrow Transplantation Volume 22, Issue 3, Pages S56-S57 (March 2016) DOI: 10.1016/j.bbmt.2015.11.345 Copyright © 2016 Terms and Conditions

Figure 1 Epithelial organoid culture system. Crypts cultured in Matrigel with EGF, Noggin, and R-spondin-1 form intestinal organoid structures, and organoid growth was used as a model of intestinal regeneration. A) Sorted RORyt-GFP+ ILC3s cultured with an IL-23 cytokine cocktail increase SI organoid size, which is blocked by anti- IL-22 neutralizing antibody. B) rhlL-22 increases the size of human (Hu) duodenal organoids cultured in standard expansion medium (EM), C) ISC elimination by culturing Lgr5-DTR organoids with diptheria toxin (DT) eliminates IL-22-dependent growth. D) Stat3 deficiency induced by culturing Stat3m crypts with adenoviral-Cre prevents organoid growth and response to IL-22, *p<.05, ***p<.001. Biology of Blood and Marrow Transplantation 2016 22, S56-S57DOI: (10.1016/j.bbmt.2015.11.345) Copyright © 2016 Terms and Conditions