Understanding Spontaneous Conversion: The Case of the Ly6C− Monocyte Sara Polletti, Gioacchino Natoli  Immunity  Volume 46, Issue 5, Pages 764-766 (May 2017) DOI: 10.1016/j.immuni.2017.04.010 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 A Schematic Model for the Conversion of Ly6C+ into Ly6C− Monocytes in the Mouse Monocytes receive signals from the bone marrow niche that instruct the activation of the gene expression program characteristic of Ly6C+ monocytes. Once in the blood, Ly6C+ monocytes can extravasate in response to homeostatic or danger signals, enter tissues, and terminally differentiate into macrophages. After the Ly6C+ program is extinguished, a distinct program under the control of the transcription factors C/EBPβ, KLF2, and NR4A1 is derepressed: the resulting Ly6C− monocytes remain in the blood to exert endothelium patrolling activities. Immunity 2017 46, 764-766DOI: (10.1016/j.immuni.2017.04.010) Copyright © 2017 Elsevier Inc. Terms and Conditions