Skin barrier impairment at birth predicts food allergy at 2 years of age Maeve M. Kelleher, MD, Audrey Dunn-Galvin, PhD, Claire Gray, RN, Deirdre M. Murray,

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Presentation transcript:

Skin barrier impairment at birth predicts food allergy at 2 years of age Maeve M. Kelleher, MD, Audrey Dunn-Galvin, PhD, Claire Gray, RN, Deirdre M. Murray, MD, PhD, Mairead Kiely, PhD, Louise Kenny, PhD, W.H. Irwin McLean, PhD, FRS, Alan D. Irvine, MD, PhD, Jonathan O'B. Hourihane, DM Journal of Allergy and Clinical Immunology Volume 137, Issue 4, Pages 1111-1116.e8 (April 2016) DOI: 10.1016/j.jaci.2015.12.1312 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Day 2 TEWL quartiles of infants with FA at 2 years of age. Journal of Allergy and Clinical Immunology 2016 137, 1111-1116.e8DOI: (10.1016/j.jaci.2015.12.1312) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 FA diagnosed at age 2 years with no AD by TEWL quartile. Journal of Allergy and Clinical Immunology 2016 137, 1111-1116.e8DOI: (10.1016/j.jaci.2015.12.1312) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Investigation of positive SPT responses at 2 years of age. Journal of Allergy and Clinical Immunology 2016 137, 1111-1116.e8DOI: (10.1016/j.jaci.2015.12.1312) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Relationship between AD at any time point and FA at 2 years of age. Journal of Allergy and Clinical Immunology 2016 137, 1111-1116.e8DOI: (10.1016/j.jaci.2015.12.1312) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions