Influence of haemorrhage on the pseudo-steady-state remifentanil concentration in a swine model: a comparison with propofol and the effect of haemorrhagic.

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Influence of haemorrhage on the pseudo-steady-state remifentanil concentration in a swine model: a comparison with propofol and the effect of haemorrhagic shock stage T. Kurita, M. Uraoka, K. Morita, M. Suzuki, Y. Morishima, S. Sato British Journal of Anaesthesia Volume 107, Issue 5, Pages 719-725 (November 2011) DOI: 10.1093/bja/aer233 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Individual plasma remifentanil and propofol concentrations before and during stepwise haemorrhage. The dotted line in each plot represents the concentration beyond the individual maximum SVR (uncompensated shock). British Journal of Anaesthesia 2011 107, 719-725DOI: (10.1093/bja/aer233) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 Relationship between cumulative blood loss (% estimated initial blood volume) and % increases from the prehaemorrhage plasma concentration. The linear regression lines for each relationship were evaluated for data collected at less than (compensated shock) or beyond (uncompensated shock) the individual maximum SVR. British Journal of Anaesthesia 2011 107, 719-725DOI: (10.1093/bja/aer233) Copyright © 2011 The Author(s) Terms and Conditions

Fig 3 Relationships between plasma remifentanil or propofol concentrations and the reciprocal of CO. The linear regression lines for each relationship were evaluated for data collected at less than (compensated shock) and beyond (uncompensated shock) the individual maximum SVR. British Journal of Anaesthesia 2011 107, 719-725DOI: (10.1093/bja/aer233) Copyright © 2011 The Author(s) Terms and Conditions