Goserelin Acetate (Zoladex)∗with or without Hormone Replacement Therapy for the Treatment of Endometriosis Kamran S Moghissi, M.D., William D Schlaff,

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Goserelin Acetate (Zoladex)∗with or without Hormone Replacement Therapy for the Treatment of Endometriosis Kamran S Moghissi, M.D., William D Schlaff, M.D., David L Olive, M.D., Michael A Skinner, B.S., Helen Yin, M.S. Fertility and Sterility Volume 69, Issue 6, Pages 1056-1062 (June 1998) DOI: 10.1016/S0015-0282(98)00086-7

FIGURE 1 Mean values for total pelvic symptom score. The decrease in total pelvic symptom score was significantly (P =.011) greater for HRT1 than for the HRT0 or HRT2 at week 12 and significantly (P =.003) less for HRT2 than HRT0 or HRT1 at week 16. Fertility and Sterility 1998 69, 1056-1062DOI: (10.1016/S0015-0282(98)00086-7)

FIGURE 2 Mean values for total subjective symptom score. Fertility and Sterility 1998 69, 1056-1062DOI: (10.1016/S0015-0282(98)00086-7)

FIGURE 3 Mean value of bone mineral density. Fertility and Sterility 1998 69, 1056-1062DOI: (10.1016/S0015-0282(98)00086-7)

FIGURE 4 Mean intensity scores for physiologic side effects of goserelin treatment: (A), Vaginal dryness. (B), Hot flushes. The difference in the mean score as for the HRT1 and HRT2 groups versus the HRT0 group was statistically significant for hot flushes (P <.001) at weeks 12 and 24 and for vaginal dryness (P = .007) at week 24. Fertility and Sterility 1998 69, 1056-1062DOI: (10.1016/S0015-0282(98)00086-7)