B. J. E. de Lange-Brokaar, M. Kloppenburg, S. N. Andersen, A. L

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General Information Osteoarthritis and Cartilage

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Characterization of synovial mast cells in knee osteoarthritis: association with clinical parameters B.J.E. de Lange-Brokaar, M. Kloppenburg, S.N. Andersen, A.L. Dorjée, E. Yusuf, L. Herb-van Toorn, H.M. Kroon, A.-M. Zuurmond, V. Stojanovic-Susulic, J.L. Bloem, R.G.H.H. Nelissen, R.E.M. Toes, A. Ioan-Facsinay Osteoarthritis and Cartilage Volume 24, Issue 4, Pages 664-671 (April 2016) DOI: 10.1016/j.joca.2015.11.011 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Paraffin sections were stained for DAPI, CD117 and tryptase as described in Materials and methods. Individual stainings and the overlay (right column) are presented, as well as examples of degranulated and non-degranulated mast cells, isotype stainings and overview images. All pictures were taken on 40× magnification. We digitally zoomed-in in the overview pictures to select examples of non-degranulated and degranulated mast cells. Osteoarthritis and Cartilage 2016 24, 664-671DOI: (10.1016/j.joca.2015.11.011) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Total mast cell numbers in 10 high power fields in A) total OA and RA population, B) early and late OA and RA populations are depicted. The percent degranulated mast cells in the total OA and RA population (C) or early and late OA and RA populations (D) is depicted. Each dot represents one patient. The median per group is indicated. P-values for differences between groups (as indicated) tested by Mann–Whitney (A–C) or Kruskal–Wallis (D) are depicted. Osteoarthritis and Cartilage 2016 24, 664-671DOI: (10.1016/j.joca.2015.11.011) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Synovitis scores determined by H&E staining (as described in Materials and methods) in A) total OA and RA population or B) early and late OA and RA populations are depicted. Each dot represents one patient. The median per group is indicated. P-values for differences between groups (as indicated) tested by Student's t test are depicted. Osteoarthritis and Cartilage 2016 24, 664-671DOI: (10.1016/j.joca.2015.11.011) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 The correlation between total number of mast cells and synovitis scores (determined by H&E staining) is presented in OA, closed circles and RA, open squares patients. Each dot represents one individual. Spearman's correlation coefficient and P-values are presented for each group. Osteoarthritis and Cartilage 2016 24, 664-671DOI: (10.1016/j.joca.2015.11.011) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 A) The correlation between number of mast cells and VAS pain is depicted. Differences in mast cell numbers between patients with low KL scores (KL1 and KL2) and high KL scores (KL3 and KL4) were evaluated in the total OA population (B), as well as in females (C) and (D) males. P-values were determined by Mann–Whitney. Osteoarthritis and Cartilage 2016 24, 664-671DOI: (10.1016/j.joca.2015.11.011) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions