Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations  Toshiko Tanaka, Paul Scheet, Betti Giusti, Stefania Bandinelli, Maria Grazia Piras, Gianluca Usala, Sandra Lai, Antonella Mulas, Anna Maria Corsi, Anna Vestrini, Francesco Sofi, Anna Maria Gori, Rosanna Abbate, Jack Guralnik, Andrew Singleton, Goncalo R. Abecasis, David Schlessinger, Manuela Uda, Luigi Ferrucci  The American Journal of Human Genetics  Volume 84, Issue 4, Pages 477-482 (April 2009) DOI: 10.1016/j.ajhg.2009.02.011 Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 1 Genome-wide Scans of Plasma Vitamin B12 and B6 in the InCHIANTI Study on Aging (A) Genome-wide associations of plasma vitamin B6 graphed by chromosome position and −log10 p value. The most significant variant was in the ALPL and NBPF3 genes on chromosome 1. (B) Genome-wide associations of plasma vitamin B12 graphed by chromosome position and −log10 p value. The most significant variant was in the FUT2 gene on chromosome 19. The next genes of interested included CUBN gene on chromosome 10 and TCN1 on chromosome 11. (C) Genome-wide associations of plasma homocysteine graphed by chromosome position and −log10 p value. The most significant variant was in the MTHFR gene on chromosome 1. The second significant region was in the SYT9 gene on chromosome 11. The American Journal of Human Genetics 2009 84, 477-482DOI: (10.1016/j.ajhg.2009.02.011) Copyright © 2009 The American Society of Human Genetics Terms and Conditions