Figure DPPX antibodies as detected by fluorescence-based immunohistochemistry and a cell-based assayImmunohistochemistry displayed binding of the patient's.

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Nat. Rev. Neurol. doi: /nrneurol

Figure 2 GlyR antibody binding

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Figure. Patient imaging

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Figure 3. Sensitivity and specificity of microarray analysis in relation to target number Sensitivity and specificity of microarray analysis in relation.

Figure 3 C5B3 blocked MAC formation

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Presentation transcript:

Figure DPPX antibodies as detected by fluorescence-based immunohistochemistry and a cell-based assayImmunohistochemistry displayed binding of the patient's serum immunoglobulin G (IgG) to rat hippocampus (A), primate myenteric plexus (B), and mouse (C) and primate (D) cerebellum tissue sections in a staining pattern compatible with dipeptidyl-peptidase-like protein-6 (DPPX) antibodies. DPPX antibodies as detected by fluorescence-based immunohistochemistry and a cell-based assayImmunohistochemistry displayed binding of the patient's serum immunoglobulin G (IgG) to rat hippocampus (A), primate myenteric plexus (B), and mouse (C) and primate (D) cerebellum tissue sections in a staining pattern compatible with dipeptidyl-peptidase-like protein-6 (DPPX) antibodies. Specificity for DPPX was confirmed in a cell-based assay by binding of the patient's IgG to HEK293 cells transfected with human DPPX (E) but not to mock-transfected cells (F). IgG was detected using a fluorescein isothiocyanate–conjugated antibody from goat (green). Katharina Stoeck et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e86 © 2015 American Academy of Neurology