Acquired von Willebrand Syndrome in Continuous-Flow Ventricular Assist Device Recipients Sheri Crow, MD, Dong Chen, MD, PhD, Carmelo Milano, MD, William.

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Acquired von Willebrand Syndrome in Continuous-Flow Ventricular Assist Device Recipients Sheri Crow, MD, Dong Chen, MD, PhD, Carmelo Milano, MD, William Thomas, PhD, Lyle Joyce, MD, PhD, Valentino Piacentino, MD, PhD, Riti Sharma, MD, Jogin Wu, PhD, Gowthami Arepally, MD, Dawn Bowles, PhD, Joseph Rogers, MD, Nestor Villamizar-Ortiz, MD The Annals of Thoracic Surgery Volume 90, Issue 4, Pages 1263-1269 (October 2010) DOI: 10.1016/j.athoracsur.2010.04.099 Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 High molecular weight von Willebrand factor multimer grading: the gel reflects increasing severity of multimer loss from left to right. Grade 0 indicates normal levels with no multimer loss, grade 2 indicates moderate multimer loss, and grade 3 indicates severe multimer loss. (LVAD = left ventricular assist device.) The Annals of Thoracic Surgery 2010 90, 1263-1269DOI: (10.1016/j.athoracsur.2010.04.099) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 High molecular weight von Willebrand factor multimer grade loss surrounding continuous-flow left ventricular assist device (LVAD) implantation is shown. The Annals of Thoracic Surgery 2010 90, 1263-1269DOI: (10.1016/j.athoracsur.2010.04.099) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 von Willebrand factor antigen (vWF:Ag): (A) Responses from individual patients; bleeders are indicated by black lines, nonbleeders by gray lines. (B) Mean ± SE for bleeders (black) and nonbleeders (gray). (VAD = ventricular assist device.) The Annals of Thoracic Surgery 2010 90, 1263-1269DOI: (10.1016/j.athoracsur.2010.04.099) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Factor VIII: (A) Responses from individual patients; bleeders are indicated by black lines, nonbleeders by gray lines. (B) Mean ± SE for bleeders (black) and nonbleeders (gray). (VAD = ventricular assist device.) The Annals of Thoracic Surgery 2010 90, 1263-1269DOI: (10.1016/j.athoracsur.2010.04.099) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions