Commensal Fungi in Health and Disease

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Commensal Fungi in Health and Disease Jose J. Limon, Joseph H. Skalski, David M. Underhill Cell Host & Microbe Volume 22, Issue 2, Pages 156-165 (August 2017) DOI: 10.1016/j.chom.2017.07.002 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Alterations in Commensal Fungi May Affect the Host in Diverse Ways Changing intestinal fungi either by adding (probiotic) or subtracting (antifungal drugs) organisms can alter the makeup of the bacterial microbiota (1). Fungi detected by the intestinal immune system can lead to inflammatory or tolerant immune responses and can direct immune cell trafficking (2). Phagocytes digesting fungi can release fungal-derived molecules into circulation that may have immunoregulatory effects (3). Finally, intestinal fungi release and consume metabolites that can lead to activation or suppression of immune responses (4). Cell Host & Microbe 2017 22, 156-165DOI: (10.1016/j.chom.2017.07.002) Copyright © 2017 Elsevier Inc. Terms and Conditions