Diagnostic and Therapeutic Yield of Endoscopy in Patients with Elevated INR and Gastrointestinal Bleeding Joanna M. Peloquin, MD, Siamak M. Seraj, MD,

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Diagnostic and Therapeutic Yield of Endoscopy in Patients with Elevated INR and Gastrointestinal Bleeding Joanna M. Peloquin, MD, Siamak M. Seraj, MD, MPH, Lindsay Y. King, MD, MPH, Emily J. Campbell, MPH, Ashwin N. Ananthakrishnan, MBBS, MPH, James M. Richter, MD, MA The American Journal of Medicine Volume 129, Issue 6, Pages 628-634 (June 2016) DOI: 10.1016/j.amjmed.2015.11.030 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure Likelihood of significant finding at upper endoscopy (EGD) increases with increasing risk score. The risk score is calculated by assigning 1 point each for concomitant antiplatelet therapy and an EGD performed within 12 hours, with 0, 1, and 2 points for an international normalized ratio of > 7.5, 5.5-7.5, and < 5.5, respectively. Each 1-point increase in this prediction score was associated with a twofold increase in likelihood of a significant endoscopic finding (odds ratio [OR] 2.15; 95% confidence interval [CI], 1.36-3.40) and a threefold increase in likelihood of a therapeutic intervention at EGD (OR 2.87; 95% CI, 1.55-5.31). The American Journal of Medicine 2016 129, 628-634DOI: (10.1016/j.amjmed.2015.11.030) Copyright © 2016 Elsevier Inc. Terms and Conditions