Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.

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Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. (A) Depletion protocol: 9-wk-old MISTRG mice were treated on three consecutive days with 50 μg of OKT8 (black arrows), followed by infection with 200,000 TCID50 of YU-2 (red arrow). Depletion was confirmed in the peripheral blood by flow cytometry at different times (T0, T2, T4, and T5 wk). (B) HIV viral load (MISTRG HIV+, n = 5–10; MISTRG HIV+ OKT8, n = 8–10). (C) CD4+ T cell frequencies in the spleen after sacrifice at 5 wk p.i. (MISTRG HIV− [red stippled bar], n = 7; MISTRG HIV+ [red bar], n = 6; MISTRG HIV+ OKT8 [black bar], n = 8; MISTRG HIV− OKT8 [black stippled bar], n = 4). **p < 0.01, Kruskal–Wallis test with the Dunn multiple-comparison test. Data are mean ± SEM. (D) Distribution of different CD4+ T cell subsets in the spleen at 5 wk p.i. **p < 0.01, two-tailed Mann–Whitney U test. Sandra Ivic et al. ImmunoHorizons 2017;1:162-175 Copyright © 2017 The Authors