Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature.

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Presentation transcript:

Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review  Thomas I. Siebert, M.D., Thinus F. Kruger, M.D., Daniel W. Steyn, M.D., Saleema Nosarka, M.D.  Fertility and Sterility  Volume 86, Issue 5, Pages 1432-1437 (November 2006) DOI: 10.1016/j.fertnstert.2006.06.014 Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Group 1: Four trials where the addition of metformin was randomized in a prospective double-blind placebo-controlled fashion in the CC-resistant patient. Siebert. Metformin in clomiphene-resistant PCOS. Fertil Steril 2006. Fertility and Sterility 2006 86, 1432-1437DOI: (10.1016/j.fertnstert.2006.06.014) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Group 2: Two trials where the addition of metformin was prospectively randomized in the CC-resistant patient. Siebert. Metformin in clomiphene-resistant PCOS. Fertil Steril 2006. Fertility and Sterility 2006 86, 1432-1437DOI: (10.1016/j.fertnstert.2006.06.014) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Pooled data of groups 1 and 2. Siebert. Metformin in clomiphene-resistant PCOS. Fertil Steril 2006. Fertility and Sterility 2006 86, 1432-1437DOI: (10.1016/j.fertnstert.2006.06.014) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

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