Steven W. Yancey, MSc, Hector G. Ortega, MD, Oliver N

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered- dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder.

Risk of an asthma exacerbation after bariatric surgery in adults

Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement Shradha Agarwal, MD, Charlotte Cunningham-Rundles,

Asthma exacerbations: Origin, effect, and prevention

Alalia Berry, MD, William W. Busse, MD

Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement Shradha Agarwal, MD, Charlotte Cunningham-Rundles,

Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study

Is 9 more than 2 also in allergic airway inflammation?

Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial Marko Kalliomäki, MD, PhD,

Acute and chronic systemic corticosteroid–related complications in patients with severe asthma Patrick Lefebvre, MA, Mei Sheng Duh, MPH, ScD, Marie-Hélène.

Lung function decline and variable airway inflammatory pattern: Longitudinal analysis of severe asthma Christopher Newby, PhD, Joshua Agbetile, MRCP,

Eric D. Bateman, MD, Helen K

Hospitalization rates and prognosis of patients with anaphylactic shock in Denmark from 1995 through 2012 Anni Nørgaard Jeppesen, MD, Christian Fynbo.

NAEPP Expert Panel Report

Journal of Allergy and Clinical Immunology

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Safety of formoterol in patients with asthma: Combined analysis of data from double- blind, randomized controlled trials Harold Nelson, MD, Catherine.

The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: A systematic review and meta-analysis of randomized controlled trials

Anti–IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison William Busse, MD, Geoffrey Chupp,

Etiology of asthma exacerbations

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature Jessica P. Rajan, MD, Nathan E. Wineinger,

Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma Hector Ortega, MD, ScD, Steven W. Yancey, MS,

Necdet B. Gunsoy, PhD, Sarah M. Cockle, PhD, Steven W

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12- month follow-up analysis Pranabashis Haldar, MD, Christopher E. Brightling,

Risk of congenital malformations for asthmatic pregnant women using a long-acting β2- agonist and inhaled corticosteroid combination versus higher-dose.

High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects William Busse, MD, Sheldon Spector, MD, Karin Rosén,

Early decreases in blood eosinophil levels with reslizumab

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Increasing rate of hospitalizations for food-induced anaphylaxis in Italian children: An analysis of the Italian Ministry of Health database Rita Nocerino,

Justin R. Chen, MD, Brett L. Buchmiller, MD, David A. Khan, MD

News Beyond Our Pages Journal of Allergy and Clinical Immunology

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

What is an “eosinophilic phenotype” of asthma?

Endotyping early childhood asthma by quantitative symptom assessment

Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma Hector Ortega, MD, ScD, Steven W. Yancey, MS,

Autophagy: Nobel Prize 2016 and allergy and asthma research

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Effectiveness of voriconazole in the treatment of Aspergillus fumigatus–associated asthma (EVITA3 study) Joshua Agbetile, MD, Michelle Bourne, RGN, Abbie.

Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered- dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder.

Matthew J. Loza, PhD, Bao-Li Chang, PhD

Prevention of food allergy: Beyond peanut

Bruce G. Bender, PhD, Alex Pedan, PhD, Laleh T. Varasteh, RPh, MSF

Therapeutic strategies to reduce asthma exacerbations

News Beyond Our Pages Journal of Allergy and Clinical Immunology

The impact of a history of asthma on long-term outcomes of people with newly diagnosed chronic obstructive pulmonary disease: A population study Tetyana.

Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis Philippe-Jean Bousquet, MD, Christophe Combescure, PhD,

George Philip, MD, Carolyn M

Pınar Uysal, MD, Esben Eller, MSc, PhD, Charlotte G

Severity assessment in asthma: An evolving concept

The Editors' Choice Journal of Allergy and Clinical Immunology

Macrolide antibiotics and asthma treatment

Neil W. Johnston, MSc, Sebastian L. Johnston, MD, PhD, Joanne M

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Environmental factors and eosinophilic esophagitis

Paradoxical psoriasis following anti–TNF therapy in ankylosing spondylitis: A population- based cohort study Jung Min Bae, MD, PhD, Hyuck Sun Kwon, MD,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Escalating incidence of eosinophilic esophagitis: A 20-year prospective, population- based study in Olten County, Switzerland Petr Hruz, MD, PhD, Alex.

Natural history of cow’s milk allergy

Modeling asthma exacerbations through lung function in children

Mepolizumab efficacy in patients with severe eosinophilic asthma receiving different controller therapies Frank C. Albers, MD, PhD, Robert G. Price,

Presentation transcript:

Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma Steven W. Yancey, MSc, Hector G. Ortega, MD, Oliver N. Keene, MSc, Bhabita Mayer, MSc, Necdet B. Gunsoy, PhD, Christopher E. Brightling, PhD, Eugene R. Bleecker, MD, Pranabashis Haldar, MRCP, Ian D. Pavord, FMedSci Journal of Allergy and Clinical Immunology Volume 139, Issue 4, Pages 1167-1175.e2 (April 2017) DOI: 10.1016/j.jaci.2016.08.008 Copyright © 2016 GlaxoSmithKline Terms and Conditions

Fig 1 Flow of study identification, inclusion, and exclusion. Studies excluded: GSK Study 114092 (NCT01366521),25 GSK Study 115661 (NCT01842607),26 Prazma et al,27 Haldar et al,28 GSK study 201318 (genetic substudy),29 Antoniu,30 Flood-Page et al,31 and Nair et al.18 Journal of Allergy and Clinical Immunology 2017 139, 1167-1175.e2DOI: (10.1016/j.jaci.2016.08.008) Copyright © 2016 GlaxoSmithKline Terms and Conditions

Fig 2 Meta-analysis of proportion of patients with 1 or more exacerbation requiring hospitalization or hospitalization/ER visit for all doses (A) and 75 mg IV/100 mg SC (pooled) doses of mepolizumab (B) versus placebo. Heterogeneity in hospitalization data: I2 = (A) 0% (95% CI, 0-69), (B) 0% (95% CI, 0-0); heterogeneity in hospitalization/ER visit data: I2 = (A) 0% (95% CI, 0-72), (B) 0% (95% CI, 0-0). ER, Emergency room; Mepo, mepolizumab. *Relative risk not calculated for SIRIUS, but data included in the meta-analysis. †Data not available for Haldar et al.15 Journal of Allergy and Clinical Immunology 2017 139, 1167-1175.e2DOI: (10.1016/j.jaci.2016.08.008) Copyright © 2016 GlaxoSmithKline Terms and Conditions

Fig 3 Kaplan-Meier cumulative incidence curve for time to first exacerbation requiring hospitalization (A) and hospitalization and/or ER visit (B). ER, Emergency room. Journal of Allergy and Clinical Immunology 2017 139, 1167-1175.e2DOI: (10.1016/j.jaci.2016.08.008) Copyright © 2016 GlaxoSmithKline Terms and Conditions

Fig 4 Meta-analysis of rate of exacerbations requiring hospitalization or hospitalization/ER visit for all doses of mepolizumab versus placebo. Heterogeneity in hospitalization data: I2 = 0% (95% CI, 0-53); heterogeneity in hospitalization/ER visit data: I2 = 0% (95% CI, 0-22). ER, Emergency room; Mepo, mepolizumab. *SIRIUS not included because there were no hospitalizations in the Mepo arm. †Haldar et al15 not included because data were not available for ER visits. Journal of Allergy and Clinical Immunology 2017 139, 1167-1175.e2DOI: (10.1016/j.jaci.2016.08.008) Copyright © 2016 GlaxoSmithKline Terms and Conditions

Fig E1 Meta-analysis of rate of exacerbations requiring hospitalization or hospitalization/ER visit for 75 mg IV/100 mg SC (pooled) doses of mepolizumab versus placebo. Heterogeneity in hospitalization data: I2 = 0% (95% CI, 0-0); heterogeneity in hospitalization/ER visit data: I2 = 0% (95% CI, 0-0). ER, Emergency room; Mepo, mepolizumab. Journal of Allergy and Clinical Immunology 2017 139, 1167-1175.e2DOI: (10.1016/j.jaci.2016.08.008) Copyright © 2016 GlaxoSmithKline Terms and Conditions