Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism Marine Germain, Daniel I. Chasman,

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Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism Marine Germain, Daniel I. Chasman, Hugoline de Haan, Weihong Tang, Sara Lindström, Lu-Chen Weng, Mariza de Andrade, Marieke C.H. de Visser, Kerri L. Wiggins, Pierre Suchon, Noémie Saut, David M. Smadja, Grégoire Le Gal, Astrid van Hylckama Vlieg, Antonio Di Narzo, Ke Hao, Christopher P. Nelson, Ares Rocanin-Arjo, Lasse Folkersen, Ramin Monajemi, Lynda M. Rose, Jennifer A. Brody, Eline Slagboom, Dylan Aïssi, France Gagnon, Jean-Francois Deleuze, Panos Deloukas, Christophe Tzourio, Jean-Francois Dartigues, Claudine Berr, Kent D. Taylor, Mete Civelek, Per Eriksson, Bruce M. Psaty, Jeanine Houwing-Duitermaat, Alison H. Goodall, François Cambien, Peter Kraft, Philippe Amouyel, Nilesh J. Samani, Saonli Basu, Paul M. Ridker, Frits R. Rosendaal, Christopher Kabrhel, Aaron R. Folsom, John Heit, Pieter H. Reitsma, David-Alexandre Trégouët, Nicholas L. Smith, Pierre-Emmanuel Morange The American Journal of Human Genetics Volume 96, Issue 4, Pages 532-542 (April 2015) DOI: 10.1016/j.ajhg.2015.01.019 Copyright © 2015 The American Society of Human Genetics Terms and Conditions

Figure 1 Regional Association Plot at the TSPAN15 Locus Association results were derived from the meta-analysis of 12 GWASs (top) that were further conditioned on the effect of TSPAN15 rs7870713 (bottom). SNPs are colored according to their pairwise LD r2 with the lead rs7870713. r2 was estimated from 1000 Genomes (Mar 2012 Eur) database. The American Journal of Human Genetics 2015 96, 532-542DOI: (10.1016/j.ajhg.2015.01.019) Copyright © 2015 The American Society of Human Genetics Terms and Conditions

Figure 2 Regional Association Plot at the SLC44A2 Locus Association results were derived from the meta-analysis of 12 GWASs (top) that were further conditioned on the effect of SLC44A2 rs2288904 (bottom). SNPs are colored according to their pairwise LD r2 with the lead rs2288904. r2 was estimated from 1000 Genomes (Mar 2012 Eur) database. The American Journal of Human Genetics 2015 96, 532-542DOI: (10.1016/j.ajhg.2015.01.019) Copyright © 2015 The American Society of Human Genetics Terms and Conditions