As-needed use of fluticasone propionate nasal spray reduces symptoms of seasonal allergic rhinitis Albert Jen, MD, Fuad Baroody, MD, Marcy de Tineo,

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Presentation transcript:

As-needed use of fluticasone propionate nasal spray reduces symptoms of seasonal allergic rhinitis Albert Jen, MD, Fuad Baroody, MD, Marcy de Tineo, BSN, Lauran Haney, BSc, Christopher Blair, BSc, Robert Naclerio, MD Journal of Allergy and Clinical Immunology Volume 105, Issue 4, Pages 732-738 (April 2000) DOI: 10.1067/mai.2000.105225 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Ragweed counts and number of subjects enrolled for duration of study. The x axis represents various days during ragweed season, and y axis represents number of subjects enrolled on each specific day (diamonds) and the ragweed counts on those days (open bars). Levels of ragweed <40 grains/mm3(dashed line) are considered low. Journal of Allergy and Clinical Immunology 2000 105, 732-738DOI: (10.1067/mai.2000.105225) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Total symptom scores for duration of study. Median total symptom scores are shown for placebo (open circles) and fluticasone propionate nasal spray (closed circles) treatment groups. Asterisk, P < .05 versus placebo on days indicated. Journal of Allergy and Clinical Immunology 2000 105, 732-738DOI: (10.1067/mai.2000.105225) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Individual domains for RQLQ. Median responses at each visit (V) are shown for placebo group (open circles) and fluticasone propionate nasal spray group (closed circles). Asterisk, P < .005 versus placebo. Journal of Allergy and Clinical Immunology 2000 105, 732-738DOI: (10.1067/mai.2000.105225) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 4 Total eosinophils in nasal lavage fluids during study. Median numbers obtained at each of 3 study visits are shown. Placebo group is depicted by open circles and fluticasone propionate nasal spray group by closed circles. Dagger, P = .008 versus visits 1 and 2 in fluticasone propionate nasal spray group; asterisk, P = .007 versus placebo on visit 3. Journal of Allergy and Clinical Immunology 2000 105, 732-738DOI: (10.1067/mai.2000.105225) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 5 Levels of ECP in nasal lavage fluids during study. Median levels obtained at each of 3 study visits are shown. Placebo group is depicted by open circles and fluticasone propionate nasal spray group by closed circles. There was no significant difference within or between groups. Journal of Allergy and Clinical Immunology 2000 105, 732-738DOI: (10.1067/mai.2000.105225) Copyright © 2000 Mosby, Inc. Terms and Conditions