Cardiorespiratory Response to Exercise Testing in Individuals With Alzheimer's Disease  Sandra A. Billinger, PT, PhD, Eric D. Vidoni, PT, PhD, Robyn A. Honea, DPhil, Jeffrey M. Burns, MD, MS  Archives of Physical Medicine and Rehabilitation  Volume 92, Issue 12, Pages 2000-2005 (December 2011) DOI: 10.1016/j.apmr.2011.07.194 Copyright © 2011 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 1 Response to exercise in our 4 primary measures of interest are displayed for all participants for the initial 6 minutes of exercise, and peak values for those who met 85% of age-predicted maximal HR and RER of ≥1.0. Filled shapes represent the nondemented group, and open shapes represent the group with AD. (A) Vo2 rose significantly faster during the initial 6 minutes of the test during 2-year follow-up testing (right graph). Vo2peak was greater in the nondemented group at both time points. (B) At follow-up testing, the AD group began testing with a lower HR but increased over the initial 6 minutes of testing to match the nondemented group, resulting in an interaction of Test Minute and Group. Peak HRs were different between groups at baseline testing but not at follow-up. (C) In both groups, Ve rose at a faster rate during the initial 6 minutes of exercise testing at follow-up compared with baseline, resulting in a significant interaction between Study Visit and Test Minute. Peak Ve was greater in the nondemented group at baseline. (D) Ve/Vo2 (left Y axis) and Ve/Vco2 (right Y axis) are presented together for ease of comparison. Interaction of Test Minute and Study Visit was evident for both measures, with a steeper decline in V̇e/Vco2 and an earlier rebound in Ve/Vo2 at follow-up testing. Peak values were not different between groups. Archives of Physical Medicine and Rehabilitation 2011 92, 2000-2005DOI: (10.1016/j.apmr.2011.07.194) Copyright © 2011 American Congress of Rehabilitation Medicine Terms and Conditions