Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos Alberto Tejera, Ph.D., Javier Herrero, Ph.D.,

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Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos Alberto Tejera, Ph.D., Javier Herrero, Ph.D., Thamara Viloria, Ph.D., Josep Lluis Romero, M.D., Pilar Gamiz, Ph.D., Marcos Meseguer, Ph.D. Fertility and Sterility Volume 98, Issue 4, Pages 849-857.e3 (October 2012) DOI: 10.1016/j.fertnstert.2012.06.040 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Time-dependent embryo O2 consumption. Averages in each of four time ranges. Fertility and Sterility 2012 98, 849-857.e3DOI: (10.1016/j.fertnstert.2012.06.040) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Time-dependent embryo O2 consumption. Averages from transferred embryos in each of the four time ranges depending on implantation success. *Significant difference (P<.05) between implanted embryos and nonimplanted embryos. Fertility and Sterility 2012 98, 849-857.e3DOI: (10.1016/j.fertnstert.2012.06.040) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Time-dependent O2 consumption for transferred embryos. Averages in each of the four time ranges for the embryos that achieved an ongoing pregnancy and those that did not. *Significant difference (P<.05) between transferred embryos that generated an ongoing pregnancy and those that did not at different time ranges. Fertility and Sterility 2012 98, 849-857.e3DOI: (10.1016/j.fertnstert.2012.06.040) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Time-dependent embryo O2 consumption. Averages in each of the four time ranges depending on final embryo viability. *Significant difference (P<.001) between transferred/frozen and nonviable embryos. Fertility and Sterility 2012 98, 849-857.e3DOI: (10.1016/j.fertnstert.2012.06.040) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions