Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis Kazue Yoshida,

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Presentation transcript:

Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis Kazue Yoshida, MD, PhD, Akiharu Kubo, MD, PhD, Harumi Fujita, PhD, Mariko Yokouchi, MD, Ken Ishii, MD, PhD, Hiroshi Kawasaki, MD, PhD, Toshifumi Nomura, MD, PhD, Hiroshi Shimizu, MD, PhD, Keisuke Kouyama, MD, PhD, Tamotsu Ebihara, MD, PhD, Keisuke Nagao, MD, PhD, Masayuki Amagai, MD, PhD Journal of Allergy and Clinical Immunology Volume 134, Issue 4, Pages 856-864 (October 2014) DOI: 10.1016/j.jaci.2014.08.001 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 3D visualization of epidermal TJs and LCs in healthy human epidermis. A and B, TJs and HLA-DRperinuclear LCs in en face (Fig 1, A and B, left) and 90° rotation images (Fig 1, B, right; see Video 1). C, TJ penetration (arrow) of an LC dendrite and langerin accumulation (arrowheads). The center region of the left panel is enlarged in the right panels (see Video 2). Journal of Allergy and Clinical Immunology 2014 134, 856-864DOI: (10.1016/j.jaci.2014.08.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Interaction of epidermal DCs with TJs. A, TJ network (occludin), langerin− IDECs (arrowheads), and TJ penetration of HLA-DRhigh activated LCs (arrows) in patients with AD. B-E, Mean numbers represent the following: LCs per view (0.06 mm2; Fig 2, B), TJ-penetrating LCs per view (Fig 2, C), IDECs per view (Fig 2, D), and TJ-penetrating IDECs per view (Fig 2, E). Two to 5 views were observed for counting in each subject. n, Number of subjects. Error bars represent SEM. Journal of Allergy and Clinical Immunology 2014 134, 856-864DOI: (10.1016/j.jaci.2014.08.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Different relationships of LCs and IDECs with TJs in patients with AD. A, TJ penetration of HLA-DRhigh activated LCs (yellow arrows) and habitation below the TJs of HLA-DRperinuclear steady-state LCs (open arrowheads) and langerin− IDECs (yellow arrowheads) in a 90°-rotated 3D image of AD skin (see Video 3). B and C, Distance from the TJ (Fig 3, B) and angle of the dendrites (Fig 3, C). n, Number of DCs. Error bars represent SEM. Journal of Allergy and Clinical Immunology 2014 134, 856-864DOI: (10.1016/j.jaci.2014.08.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Distribution of FcεRI and langerin on LCs in AD skin. A and B, HLA-DRhigh activated LC (arrow) and HLA-DRperinuclear steady-state LC (open arrowhead). Fig 4, B, shows a 90° rotation image of the dashed rectangular area of Fig 4, A, showing TJ penetration of the LC (yellow arrow; see Video 5). C, Distribution of langerin and FcεRI on TJ-penetrated LC dendrites (yellow arrows; see Video 6). Journal of Allergy and Clinical Immunology 2014 134, 856-864DOI: (10.1016/j.jaci.2014.08.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2014 134, 856-864DOI: (10.1016/j.jaci.2014.08.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2014 134, 856-864DOI: (10.1016/j.jaci.2014.08.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2014 134, 856-864DOI: (10.1016/j.jaci.2014.08.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2014 134, 856-864DOI: (10.1016/j.jaci.2014.08.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions