A RHIM with a View: FLYing with Functional Amyloids

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A RHIM with a View: FLYing with Functional Amyloids Sunny Shin, Sara Cherry Immunity Volume 47, Issue 4, Pages 604-606 (October 2017) DOI: 10.1016/j.immuni.2017.10.001 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 cRHIMS Drive IMD Pathway Activation through Functional Amyloid Formation DAP-type PGN can activate IMD signaling either at the plasma membrane by binding to PGRP-LC or from the cytoplasm by binding intracellular PGRP-LE. Kleino et al. (2017) show that this leads to cRHIM-mediated nucleation, which must then incorporate the cRHIM of Imd to form a fibril. This presents the DD of Imd to the downstream signaling components including FADD, which interacts through its DD. Pirk contains a cRHIM that can interact with the cRHIMs of Imd or PGRPs and thereby block amyloid formation preventing signaling. Immunity 2017 47, 604-606DOI: (10.1016/j.immuni.2017.10.001) Copyright © 2017 Elsevier Inc. Terms and Conditions