Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders Liang Qiang, Ryousuke Fujita, Asa Abeliovich Neuron

Slides:

Advertisements

Similar presentations

Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala Marina A. Belova, Joseph J. Paton, Sara E. Morrison, C. Daniel.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The Will to Persevere Induced by Electrical Stimulation of the Human Cingulate Gyrus Josef Parvizi, Vinitha Rangarajan, William R. Shirer, Nikita Desai,

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons Mitsuko Watabe-Uchida, Lisa Zhu, Sachie K. Ogawa, Archana Vamanrao, Naoshige Uchida Neuron.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

Disrupted Neural Synchronization in Toddlers with Autism Ilan Dinstein, Karen Pierce, Lisa Eyler, Stephanie Solso, Rafael Malach, Marlene Behrmann, Eric.

Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others Jason P. Mitchell, C. Neil Macrae, Mahzarin R. Banaji Neuron.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)

Rare Inherited Variation in Autism: Beginning to See the Forest and a Few Trees Jason L. Stein, Neelroop N. Parikshak, Daniel H. Geschwind Neuron Volume.

Volume 70, Issue 4, Pages (May 2011)

Volume 70, Issue 4, Pages (May 2011)

How to Remake a Fibroblast into a Neural Stem Cell

Keeping ‘Trk’ of Antidepressant Actions

A New Chapter in the Life of Cajal’s Short-Axon Neurons: Separation of Interneuron Siblings after Birth Cristina Gil-Sanz, Ulrich Müller Neuron Volume.

Volume 16, Issue 6, Pages (June 2015)

Upgrading from iMac to iMicro

The Tanenbaum Open Science Institute: Leading a Paradigm Shift at the Montreal Neurological Institute Viviane Poupon, Annabel Seyller, Guy A. Rouleau

Pluripotent Stem Cells from Cloned Human Embryos: Success at Long Last

Bettina Schreiner, Melanie Greter Cell Stem Cell

Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer

Volume 21, Issue 6, Pages (December 2017)

Therapeutic Translation of iPSCs for Treating Neurological Disease

Justin Brumbaugh, Konrad Hochedlinger Cell Stem Cell

Human Somatic Cell Nuclear Transfer Is Alive and Well

Small Molecules Take a Big Step by Converting Fibroblasts into Neurons

New Neurons Don’t Talk Back

Assembling Cell Ensembles

Fibrinogen in the Nervous System: Glia Beware

Cerebral Organoids in a Dish: Progress and Prospects

Volume 68, Issue 2, Pages (October 2010)

Volume 18, Issue 2, Pages (February 2016)

Recurrent Feedback Loops in Associative Learning

Pluripotent Stem Cells and Disease Modeling

MAP'ing CNS Development and Cognition: An ERKsome Process

K+ Channel Regulation of Multicompartmental Signal Integration

Order from Chaos: Single Cell Reprogramming in Two Phases

Volume 91, Issue 6, Pages (September 2016)

Modeling Rett Syndrome with Stem Cells

Direct Conversion Provides Old Neurons from Aged Donor’s Skin

Bettina Schreiner, Melanie Greter Cell Stem Cell

A Fresh Look at iPS Cells

Volume 91, Issue 4, Pages (August 2016)

Finding the Roots of Adult Neurogenesis

Immune Cells Exploit a Neural Circuit to Enter the CNS

Chapter 29 - Stem Cells and Generation of New Cells in the

Pharmacogenomics and Personalized Medicine in Neuropsychiatry

The Cost of Brain Diseases: A Burden or a Challenge?

Santosh Kesari, Charles D. Stiles Neuron

Gerald D. Fischbach, Catherine Lord Neuron

David Hubel and Torsten Wiesel

Volume 19, Issue 4, Pages (April 2014)

Cellular Alchemy and the Golden Age of Reprogramming

Modeling Brain Disease in a Dish: Really?

Justin Brumbaugh, Konrad Hochedlinger Cell Stem Cell

Extreme Makeover: Converting One Cell into Another

Presentation transcript:

Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders Liang Qiang, Ryousuke Fujita, Asa Abeliovich Neuron Volume 78, Issue 6, Pages 957-969 (June 2013) DOI: 10.1016/j.neuron.2013.06.002 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Schematic of Reprogramming-Based Approaches for the Generation of Human Neuron Models of Disease These approaches include the generation of iPSC that are then differentiated to mature neurons, directed conversion to induced neurons or directed conversion to dividing neural progenitors, that can give rise to mature CNS cell types. Neuron 2013 78, 957-969DOI: (10.1016/j.neuron.2013.06.002) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Therapeutic Strategies and Somatic Cell Reprogramming Technologies “Personalized medicine” approaches include the generation of autologous “replacement” cells, as well as the identification of therapeutics that are particularly effective for a given individual. Neuron 2013 78, 957-969DOI: (10.1016/j.neuron.2013.06.002) Copyright © 2013 Elsevier Inc. Terms and Conditions