Volume 82, Issue 8, Pages (October 2012)

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Volume 82, Issue 8, Pages 920-927 (October 2012) Advanced age affects the outcome-predictive power of RIFLE classification in geriatric patients with acute kidney injury Chia-Ter Chao, Vin-Cent Wu, Chun-Fu Lai, Chih-Chung Shiao, Tao-Min Huang, Pei-Chen Wu, I-Jung Tsai, Chun-Cheng Hou, Wei-Jie Wang, Hung-Bin Tsai, Yu-Feng Lin, Wen-Chih Chiang, Shuei-Liong Lin, Pi-Ru Tsai, Wen-Je Ko, Ming-Shiou Wu, Kuan-Dun Wu Kidney International Volume 82, Issue 8, Pages 920-927 (October 2012) DOI: 10.1038/ki.2012.237 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Flowchart of the recruitment of study patients. AKI, acute kidney injury; ICU, intensive care unit; RRT, renal replacement therapy. Kidney International 2012 82, 920-927DOI: (10.1038/ki.2012.237) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 2 The Kaplan–Meier survival curve of the study patients divided into RIFLE-R, -I, and -F groups. RIFLE, risk, injury, failure, loss, and end-stage; RIFLE-F, RIFLE-failure; RIFLE-I, RIFLE-injury; RIFLE-R, RIFLE-risk. Kidney International 2012 82, 920-927DOI: (10.1038/ki.2012.237) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 3 The probability of in-hospital mortality associated with the chronologic age of the patients at admission to the ICU as constructed with the generalized additive model (GAM). Adjusted by sex, RIFLE category, baseline renal insufficiency, hypertension, liver cirrhosis, treatment with hemodialysis, CPR, ECMO, TPN, pacemaker implantation, and pericardiocentesis. CPR, cardiopulmonary resuscitation; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; RIFLE, risk, injury, failure, loss, and end-stage; TPN, total parenteral nutrition. Kidney International 2012 82, 920-927DOI: (10.1038/ki.2012.237) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 4 The odds ratio for hospital mortality among patients stratified by patient age and RIFLE (risk, injury, failure, loss, and end-stage) categorization (with patients aged ≤76 years and RIFLE-R category acute kidney injury as comparator). RIFLE-F, RIFLE-failure; RIFLE-I, RIFLE-injury; RIFLE-R, RIFLE-risk. Kidney International 2012 82, 920-927DOI: (10.1038/ki.2012.237) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 5 A diagram that illustrates creatinine kinetics and the potential implications for its use in the diagnosis of elderly patients with acute kidney injury (AKI). RIFLE, risk, injury, failure, loss, and end-stage; RIFLE-F, RIFLE-failure; RIFLE-I, RIFLE-injury; RIFLE-R, RIFLE-risk; sCre, serum creatinine. Kidney International 2012 82, 920-927DOI: (10.1038/ki.2012.237) Copyright © 2012 International Society of Nephrology Terms and Conditions