Figure Immune checkpoint inhibitor–induced encephalitis before and after treatment with natalizumab Immune checkpoint inhibitor–induced encephalitis before.

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Figure Immune checkpoint inhibitor–induced encephalitis before and after treatment with natalizumab Immune checkpoint inhibitor–induced encephalitis before and after treatment with natalizumab A 71-year-old woman was diagnosed in 2014 with small-cell lung cancer. In 2016, she was treated with nivolumab and ipilimumab for systemic recurrence. Four days later, she developed severe disorientation and short-term memory deficits. Brain MRI shows bilateral contrast-enhancing lesions with associated T2 hyperintensity of the hippocampi (A and B). The images normalize after 6 months of treatment with natalizumab (C and D). Andreas F. Hottinger et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e439 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.